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A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects.

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Title: A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects.
Authors: Lee AR; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Jeon SB; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea., Kwak HW; SML Biopharm, Gwanmyeong-si, Gyeonggi-do, Republic of Korea., Yang SW; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Bang YJ; SML Biopharm, Gwanmyeong-si, Gyeonggi-do, Republic of Korea., Lee SY; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Lee SW; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.; BK21 Four, Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea., Park JH; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea., Han SG; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea., Choi JW; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea., Park HJ; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.; BK21 Four, Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea., Cho ML; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea., Nam JH; SML Biopharm, Gwanmyeong-si, Gyeonggi-do, Republic of Korea.; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.
Source: Frontiers in immunology [Front Immunol] 2025 Oct 16; Vol. 16, pp. 1665998. Date of Electronic Publication: 2025 Oct 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects.
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  Data: <searchLink fieldCode="AU" term="%22Lee+AR%22">Lee AR</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+SB%22">Jeon SB</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwak+HW%22">Kwak HW</searchLink>; SML Biopharm, Gwanmyeong-si, Gyeonggi-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yang+SW%22">Yang SW</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bang+YJ%22">Bang YJ</searchLink>; SML Biopharm, Gwanmyeong-si, Gyeonggi-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SY%22">Lee SY</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SW%22">Lee SW</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.; BK21 Four, Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+SG%22">Han SG</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+JW%22">Choi JW</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+HJ%22">Park HJ</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.; BK21 Four, Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+ML%22">Cho ML</searchLink>; Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Nam+JH%22">Nam JH</searchLink>; SML Biopharm, Gwanmyeong-si, Gyeonggi-do, Republic of Korea.; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.
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