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In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen - 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima.

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Title: In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen - 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima.
Authors: Seneviratne NN; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Saliu TP; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Muhinudeen FT; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Gamage SD; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Garusinghe PS; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Chathuranga D; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Athukorala VD; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Kothalawala A; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Jayasekara AH; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Rathnayaka RK; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., De Silva UA; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Faries M; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Weragoda TH; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Wijerathne SK; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Rajagopalan U; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Senathilake KS; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Tennekoon KH; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka., Adhikari A; Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal., Samarakoon SR; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.
Source: PloS one [PLoS One] 2025 Nov 03; Vol. 20 (11), pp. e0334238. Date of Electronic Publication: 2025 Nov 03 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen - 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima.
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  Data: <searchLink fieldCode="AU" term="%22Seneviratne+NN%22">Seneviratne NN</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Saliu+TP%22">Saliu TP</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Muhinudeen+FT%22">Muhinudeen FT</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Gamage+SD%22">Gamage SD</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Garusinghe+PS%22">Garusinghe PS</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Chathuranga+D%22">Chathuranga D</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Athukorala+VD%22">Athukorala VD</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Kothalawala+A%22">Kothalawala A</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Jayasekara+AH%22">Jayasekara AH</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Rathnayaka+RK%22">Rathnayaka RK</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22De+Silva+UA%22">De Silva UA</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Faries+M%22">Faries M</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Weragoda+TH%22">Weragoda TH</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Wijerathne+SK%22">Wijerathne SK</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Rajagopalan+U%22">Rajagopalan U</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Senathilake+KS%22">Senathilake KS</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Tennekoon+KH%22">Tennekoon KH</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Adhikari+A%22">Adhikari A</searchLink>; Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.<br /><searchLink fieldCode="AU" term="%22Samarakoon+SR%22">Samarakoon SR</searchLink>; Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Colombo, Sri Lanka.
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