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cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.

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Title: cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.
Authors: Mahajan AS; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110., Dussold C; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Kim S; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110., Jarvis R; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110., Hurley LA; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Tommasini-Ghelfi S; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Park J; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208.; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208., Forsyth CM; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208.; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208., Zhang B; Division of Hematology and Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60208., Miska J; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Heimberger AB; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Mirkin CA; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208.; Department of Chemistry, Northwestern University, Evanston, IL 60208., Stegh AH; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 11; Vol. 122 (45), pp. e2409557122. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mahajan+AS%22">Mahajan AS</searchLink>; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Dussold+C%22">Dussold C</searchLink>; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Jarvis+R%22">Jarvis R</searchLink>; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Hurley+LA%22">Hurley LA</searchLink>; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.<br /><searchLink fieldCode="AU" term="%22Tommasini-Ghelfi+S%22">Tommasini-Ghelfi S</searchLink>; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208.; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208.<br /><searchLink fieldCode="AU" term="%22Forsyth+CM%22">Forsyth CM</searchLink>; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208.; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Division of Hematology and Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60208.<br /><searchLink fieldCode="AU" term="%22Miska+J%22">Miska J</searchLink>; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.<br /><searchLink fieldCode="AU" term="%22Heimberger+AB%22">Heimberger AB</searchLink>; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.<br /><searchLink fieldCode="AU" term="%22Mirkin+CA%22">Mirkin CA</searchLink>; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208.; Department of Chemistry, Northwestern University, Evanston, IL 60208.<br /><searchLink fieldCode="AU" term="%22Stegh+AH%22">Stegh AH</searchLink>; Department of Neurological Surgery, The Brain Tumor Center, Washington University School of Medicine, Alvin J. Siteman Comprehensive Cancer Center, St. Louis, MO 63110.
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