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Mitochondrial NOX4 drives atrial fibrillation via redox-dependent structural remodeling and fibrosis.

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Title: Mitochondrial NOX4 drives atrial fibrillation via redox-dependent structural remodeling and fibrosis.
Authors: Mondragon RR; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA., Vendrov AE; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Lozhkin A; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Jimenez Vazquez EN; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA., Wang S; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA., Hayami T; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA., Berenfeld O; Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA., Anumonwo JM; Departments of Internal Medicine and Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA., Isom LL; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA., Madamanchi NR; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: madamanc@med.umich.edu.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Jan; Vol. 242, pp. 391-403. Date of Electronic Publication: 2025 Nov 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mitochondrial NOX4 drives atrial fibrillation via redox-dependent structural remodeling and fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Mondragon+RR%22">Mondragon RR</searchLink>; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Vendrov+AE%22">Vendrov AE</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Lozhkin+A%22">Lozhkin A</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Jimenez+Vazquez+EN%22">Jimenez Vazquez EN</searchLink>; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Hayami+T%22">Hayami T</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Berenfeld+O%22">Berenfeld O</searchLink>; Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Anumonwo+JM%22">Anumonwo JM</searchLink>; Departments of Internal Medicine and Molecular and Integrative Physiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Isom+LL%22">Isom LL</searchLink>; Department of Pharmacology, University of Michigan, West Medical Center Dr., 230' Medical Science Research Building III, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Madamanchi+NR%22">Madamanchi NR</searchLink>; Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: madamanc@med.umich.edu.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2026 Jan; Vol. 242, pp. 391-403. <i>Date of Electronic Publication: </i>2025 Nov 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8709159 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-4596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208915849%22">08915849 </searchLink><i>NLM ISO Abbreviation: </i>Free Radic Biol Med <i>Subsets: </i>MEDLINE
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        Text: English
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              Text: 2026 Jan
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