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Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs.

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Title: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs.
Authors: Sadagopan A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA., Carson M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Zamurs EJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Garaffo N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA., Chang HJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schreiber SL; Broad Institute of MIT and Harvard, Cambridge, MA, USA. stuart_schreiber@harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. stuart_schreiber@harvard.edu., Meyerson M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. matthew_meyerson@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. matthew_meyerson@dfci.harvard.edu., Gibson WJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_gibson@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_gibson@dfci.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. william_gibson@dfci.harvard.edu.
Source: Nature chemical biology [Nat Chem Biol] 2026 May; Vol. 22 (5), pp. 783-792. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sadagopan+A%22">Sadagopan A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carson+M%22">Carson M</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zamurs+EJ%22">Zamurs EJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Garaffo+N%22">Garaffo N</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+HJ%22">Chang HJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schreiber+SL%22">Schreiber SL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. stuart_schreiber@harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. stuart_schreiber@harvard.edu.<br /><searchLink fieldCode="AU" term="%22Meyerson+M%22">Meyerson M</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. matthew_meyerson@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. matthew_meyerson@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Gibson+WJ%22">Gibson WJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_gibson@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_gibson@dfci.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. william_gibson@dfci.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2026 May; Vol. 22 (5), pp. 783-792. <i>Date of Electronic Publication: </i>2025 Nov 03.
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