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Rice bran extract ameliorates metal mixture induced cerebral cortex dysfunction: implicating the Nrf-2/HMOX-1/BDNF signalling pathway.

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Title: Rice bran extract ameliorates metal mixture induced cerebral cortex dysfunction: implicating the Nrf-2/HMOX-1/BDNF signalling pathway.
Authors: Dooka BD; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria., Orish CN; Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria. chinna.orish@uniport.edu.ng., Ezejiofor AN; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria., Umeji T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele, Rivers State, Nigeria., Nkpaa KW; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria., Okereke I; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria., Cirovic A; Faculty of Medicine, Institute of Anatomy, University of Belgrade, Belgrade, Serbia., Cirovic A; Faculty of Medicine, Institute of Anatomy, University of Belgrade, Belgrade, Serbia., Orisakwe OE; Advanced Research Centre, European University of Lefke, TR-10, Lefke, Mersin, Northern Cyprus, Turkey. orishebere@gmail.com.
Source: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2026 Feb; Vol. 39 (1), pp. 323-336. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9208478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-8773 (Electronic) Linking ISSN: 09660844 NLM ISO Abbreviation: Biometals Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rice bran extract ameliorates metal mixture induced cerebral cortex dysfunction: implicating the Nrf-2/HMOX-1/BDNF signalling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Dooka+BD%22">Dooka BD</searchLink>; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria.<br /><searchLink fieldCode="AU" term="%22Orish+CN%22">Orish CN</searchLink>; Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria. chinna.orish@uniport.edu.ng.<br /><searchLink fieldCode="AU" term="%22Ezejiofor+AN%22">Ezejiofor AN</searchLink>; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria.<br /><searchLink fieldCode="AU" term="%22Umeji+T%22">Umeji T</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele, Rivers State, Nigeria.<br /><searchLink fieldCode="AU" term="%22Nkpaa+KW%22">Nkpaa KW</searchLink>; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria.<br /><searchLink fieldCode="AU" term="%22Okereke+I%22">Okereke I</searchLink>; African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323, Choba, Port Harcourt, Nigeria.<br /><searchLink fieldCode="AU" term="%22Cirovic+A%22">Cirovic A</searchLink>; Faculty of Medicine, Institute of Anatomy, University of Belgrade, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Cirovic+A%22">Cirovic A</searchLink>; Faculty of Medicine, Institute of Anatomy, University of Belgrade, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Orisakwe+OE%22">Orisakwe OE</searchLink>; Advanced Research Centre, European University of Lefke, TR-10, Lefke, Mersin, Northern Cyprus, Turkey. orishebere@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%229208478%22">Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine</searchLink> [Biometals] 2026 Feb; Vol. 39 (1), pp. 323-336. <i>Date of Electronic Publication: </i>2025 Nov 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic+Publishers%22">Kluwer Academic Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9208478 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1572-8773 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209660844%22">09660844 </searchLink><i>NLM ISO Abbreviation: </i>Biometals <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10534-025-00765-8
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        Text: English
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              Text: 2026 Feb
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