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Exercise and hypoxia independently stimulate platelet liberation of brain-derived neurotrophic factor and platelet factor 4.

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Title: Exercise and hypoxia independently stimulate platelet liberation of brain-derived neurotrophic factor and platelet factor 4.
Authors: Thomas KN; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Caldwell HG; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Department of Nutrition, Exercise and Sports, The August Krogh Section for Molecular Physiology, University of Copenhagen, Copenhagen, Denmark., Macleod DB; Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA., Abraham WC; Department of Psychology, University of Otago, Dunedin, New Zealand., Carr JMJR; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Institute of Mountain Emergency Medicine, EURAC Research, Bolzano, Italy., Gasho C; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada., Brewster LM; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada., Bruce CD; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Institute of Sports Science, University of Innsbruck, Innsbruck, Austria., Monteleone JA; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada., Duffy JS; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada., Howe CA; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Institute of Sports Science, University of Innsbruck, Innsbruck, Austria., Tremblay JC; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales., Jenkins EJ; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales., Talbot JS; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales.; Baker Heart and Diabetes Institute, Melbourne, Australia., Stembridge M; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales., Ainslie PN; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada., Gibbons TD; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA.
Source: The Journal of physiology [J Physiol] 2026 Jan; Vol. 604 (1), pp. 282-296. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Thomas+KN%22">Thomas KN</searchLink>; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Caldwell+HG%22">Caldwell HG</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Department of Nutrition, Exercise and Sports, The August Krogh Section for Molecular Physiology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Macleod+DB%22">Macleod DB</searchLink>; Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Abraham+WC%22">Abraham WC</searchLink>; Department of Psychology, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Carr+JMJR%22">Carr JMJR</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Institute of Mountain Emergency Medicine, EURAC Research, Bolzano, Italy.<br /><searchLink fieldCode="AU" term="%22Gasho+C%22">Gasho C</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.<br /><searchLink fieldCode="AU" term="%22Brewster+LM%22">Brewster LM</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.<br /><searchLink fieldCode="AU" term="%22Bruce+CD%22">Bruce CD</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Institute of Sports Science, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Monteleone+JA%22">Monteleone JA</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.<br /><searchLink fieldCode="AU" term="%22Duffy+JS%22">Duffy JS</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.<br /><searchLink fieldCode="AU" term="%22Howe+CA%22">Howe CA</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Institute of Sports Science, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Tremblay+JC%22">Tremblay JC</searchLink>; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales.<br /><searchLink fieldCode="AU" term="%22Jenkins+EJ%22">Jenkins EJ</searchLink>; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales.<br /><searchLink fieldCode="AU" term="%22Talbot+JS%22">Talbot JS</searchLink>; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales.; Baker Heart and Diabetes Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Stembridge+M%22">Stembridge M</searchLink>; Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, Wales.<br /><searchLink fieldCode="AU" term="%22Ainslie+PN%22">Ainslie PN</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.<br /><searchLink fieldCode="AU" term="%22Gibbons+TD%22">Gibbons TD</searchLink>; Centre for Heart, Lung & Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.; Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA.
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  Data: <searchLink fieldCode="JN" term="%220266262%22">The Journal of physiology</searchLink> [J Physiol] 2026 Jan; Vol. 604 (1), pp. 282-296. <i>Date of Electronic Publication: </i>2025 Nov 03.
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