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Deactivation of ceramide de novo synthesis induces cerebral angiogenesis and microvascular remodeling post-ischemia/reperfusion in mice via mechanisms not predominated by extracellular vesicles.

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Title: Deactivation of ceramide de novo synthesis induces cerebral angiogenesis and microvascular remodeling post-ischemia/reperfusion in mice via mechanisms not predominated by extracellular vesicles.
Authors: Mohamud Yusuf A; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Hussner T; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Li A; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Hagemann N; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Hornemann T; Institute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Tertel T; Institute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Brockmeier U; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Schumacher F; Department of Pharmacology and Toxicology, Institute for Pharmacy, Freie Universität Berlin, Berlin, Germany., Kleuser B; Department of Pharmacology and Toxicology, Institute for Pharmacy, Freie Universität Berlin, Berlin, Germany., Giebel B; Institute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Gunzer M; Institute of Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Gulbins E; Institute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Hermann DM; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2026 Feb; Vol. 46 (2), pp. 393-405. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deactivation of ceramide de novo synthesis induces cerebral angiogenesis and microvascular remodeling post-ischemia/reperfusion in mice via mechanisms not predominated by extracellular vesicles.
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  Data: <searchLink fieldCode="AU" term="%22Mohamud+Yusuf+A%22">Mohamud Yusuf A</searchLink>; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hussner+T%22">Hussner T</searchLink>; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hagemann+N%22">Hagemann N</searchLink>; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hornemann+T%22">Hornemann T</searchLink>; Institute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tertel+T%22">Tertel T</searchLink>; Institute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Brockmeier+U%22">Brockmeier U</searchLink>; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Schumacher+F%22">Schumacher F</searchLink>; Department of Pharmacology and Toxicology, Institute for Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kleuser+B%22">Kleuser B</searchLink>; Department of Pharmacology and Toxicology, Institute for Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Giebel+B%22">Giebel B</searchLink>; Institute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Gunzer+M%22">Gunzer M</searchLink>; Institute of Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Gulbins+E%22">Gulbins E</searchLink>; Institute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+DM%22">Hermann DM</searchLink>; Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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  Data: <searchLink fieldCode="JN" term="%228112566%22">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</searchLink> [J Cereb Blood Flow Metab] 2026 Feb; Vol. 46 (2), pp. 393-405. <i>Date of Electronic Publication: </i>2025 Nov 03.
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              Text: 2026 Feb
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