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Thrombomodulin-Induced Prevention of Peripheral Neuropathy in Oxaliplatin-Treated Mice Involves Complement C5a Inactivation and PAR1 Activation in Addition To HMGB1 Degradation.

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Title: Thrombomodulin-Induced Prevention of Peripheral Neuropathy in Oxaliplatin-Treated Mice Involves Complement C5a Inactivation and PAR1 Activation in Addition To HMGB1 Degradation.
Authors: Maruo K; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan., Tsubota M; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan., Tajima K; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan., Matsunaga H; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan., Sekiguchi F; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan., Minami T; Pharmaceuticals Research Center, Asahi Kasei Pharma Co. Ltd, 632-1 Mifuku, Izunokuni, 410-2321, Japan., Ito A; Pharmaceuticals Research Center, Asahi Kasei Pharma Co. Ltd, 632-1 Mifuku, Izunokuni, 410-2321, Japan., Tomono Y; Department of Translational Research and Drug Development, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan., Nishibori M; Department of Translational Research and Drug Development, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan., Kawabata A; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan. kawabata@phar.kindai.ac.jp.
Source: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Nov 04; Vol. 20 (1), pp. 100. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE
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