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Drug design and synthesis of new N-substituted-thienopyridine based on 2-aminothiophene derivatives as antileishmanial agents.

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Title: Drug design and synthesis of new N-substituted-thienopyridine based on 2-aminothiophene derivatives as antileishmanial agents.
Authors: Bernardo VG; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil; Postgraduate Program in Therapeutic Innovation, Biological Sciences Center, Federal University of Pernambuco, Recife 50670-420, Brazil., de Araújo RSA; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil., de Mélo NB; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil., Coutinho REP; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil., de Sousa JMS; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, Parnaíba 64202-020, Brazil., da Silva Sousa MGG; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, Parnaíba 64202-020, Brazil., de Sousa NF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil., Dos Santos Silva WF; Group of Research on Chemical and Biological Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil., da Silva Santos-Júnior PF; Group of Research on Chemical and Biological Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil; Laboratory of Organic Synthesis and Medicinal Chemistry, Post-Graduation Program in Natural Sciences and Biotechnology, Education and Health Center, Biology and Chemistry Academic Unit, Federal University of Campina Grande (UFCG), 58175-000 Cuité, Paraíba, Brazil., da Silva TG; Postgraduate Program in Therapeutic Innovation, Biological Sciences Center, Federal University of Pernambuco, Recife 50670-420, Brazil., González ERP; Fine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), 19060-080 Presidente Prudente, São Paulo, Brazil., da Silva Junior EF; Group of Research on Chemical and Biological Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil., Scotti MT; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil., Nayarisseri A; In Silico Research Laboratory, Eminent Biosciences, 91-A, Sector-A, Mahalakshmi Nagar, Indore 452010, Madhya Pradesh, India., da Franca Rodrigues KA; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, Parnaíba 64202-020, Brazil; Department of Pathology, Dom Delgado University City, Federal University of Maranhão, São Luiz 65065-545, Brazil., Mendonça-Junior FJB; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil. Electronic address: franciscojaime@servidor.uepb.edu.br.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Jan 01; Vol. 132, pp. 118475. Date of Electronic Publication: 2025 Oct 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
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  Data: Drug design and synthesis of new N-substituted-thienopyridine based on 2-aminothiophene derivatives as antileishmanial agents.
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  Data: <searchLink fieldCode="AU" term="%22Bernardo+VG%22">Bernardo VG</searchLink>; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil; Postgraduate Program in Therapeutic Innovation, Biological Sciences Center, Federal University of Pernambuco, Recife 50670-420, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Araújo+RSA%22">de Araújo RSA</searchLink>; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Mélo+NB%22">de Mélo NB</searchLink>; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil.<br /><searchLink fieldCode="AU" term="%22Coutinho+REP%22">Coutinho REP</searchLink>; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+JMS%22">de Sousa JMS</searchLink>; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, Parnaíba 64202-020, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Sousa+MGG%22">da Silva Sousa MGG</searchLink>; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, Parnaíba 64202-020, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+NF%22">de Sousa NF</searchLink>; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+Silva+WF%22">Dos Santos Silva WF</searchLink>; Group of Research on Chemical and Biological Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Santos-Júnior+PF%22">da Silva Santos-Júnior PF</searchLink>; Group of Research on Chemical and Biological Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil; Laboratory of Organic Synthesis and Medicinal Chemistry, Post-Graduation Program in Natural Sciences and Biotechnology, Education and Health Center, Biology and Chemistry Academic Unit, Federal University of Campina Grande (UFCG), 58175-000 Cuité, Paraíba, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+TG%22">da Silva TG</searchLink>; Postgraduate Program in Therapeutic Innovation, Biological Sciences Center, Federal University of Pernambuco, Recife 50670-420, Brazil.<br /><searchLink fieldCode="AU" term="%22González+ERP%22">González ERP</searchLink>; Fine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), 19060-080 Presidente Prudente, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Junior+EF%22">da Silva Junior EF</searchLink>; Group of Research on Chemical and Biological Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970 Maceió, Alagoas, Brazil.<br /><searchLink fieldCode="AU" term="%22Scotti+MT%22">Scotti MT</searchLink>; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Nayarisseri+A%22">Nayarisseri A</searchLink>; In Silico Research Laboratory, Eminent Biosciences, 91-A, Sector-A, Mahalakshmi Nagar, Indore 452010, Madhya Pradesh, India.<br /><searchLink fieldCode="AU" term="%22da+Franca+Rodrigues+KA%22">da Franca Rodrigues KA</searchLink>; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, Parnaíba 64202-020, Brazil; Department of Pathology, Dom Delgado University City, Federal University of Maranhão, São Luiz 65065-545, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendonça-Junior+FJB%22">Mendonça-Junior FJB</searchLink>; Laboratory of Synthesis and Drug Delivery, Department of Biological Sciences, State University of Paraíba, João Pessoa 58071-160, Brazil; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil. Electronic address: franciscojaime@servidor.uepb.edu.br.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2026 Jan 01; Vol. 132, pp. 118475. <i>Date of Electronic Publication: </i>2025 Oct 31.
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        Value: 10.1016/j.bmc.2025.118475
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        Text: English
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