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Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction.

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Title: Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction.
Authors: Sałaciak K; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland., Lustyk K; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland., Jagielska A; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 16 Św. Łazarza St, 31-530 Krakow, Poland., Szafarz M; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland., Inteiro-Oliveira S; Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal., Diógenes MJ; Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal., Xapelli S; Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal., Schnur P; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK., Morton L; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK., Moran E; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK., Ferreira J; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK., Sakata S; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK., Crouzier L; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France., Meunier J; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France., Delprat B; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France., Maurice T; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France., Pytka K; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland. Electronic address: karolina.pytka@uj.edu.pl.
Source: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2026 Jan; Vol. 23 (1), pp. e00774. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics Country of Publication: United States NLM ID: 101290381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7479 (Electronic) Linking ISSN: 18787479 NLM ISO Abbreviation: Neurotherapeutics Subsets: MEDLINE
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  Data: Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction.
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  Data: <searchLink fieldCode="AU" term="%22Sałaciak+K%22">Sałaciak K</searchLink>; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Lustyk+K%22">Lustyk K</searchLink>; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Jagielska+A%22">Jagielska A</searchLink>; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 16 Św. Łazarza St, 31-530 Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Szafarz+M%22">Szafarz M</searchLink>; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Inteiro-Oliveira+S%22">Inteiro-Oliveira S</searchLink>; Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Diógenes+MJ%22">Diógenes MJ</searchLink>; Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Xapelli+S%22">Xapelli S</searchLink>; Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Schnur+P%22">Schnur P</searchLink>; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Morton+L%22">Morton L</searchLink>; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Moran+E%22">Moran E</searchLink>; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Ferreira+J%22">Ferreira J</searchLink>; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Sakata+S%22">Sakata S</searchLink>; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral St, Glasgow G4 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Crouzier+L%22">Crouzier L</searchLink>; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Meunier+J%22">Meunier J</searchLink>; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Delprat+B%22">Delprat B</searchLink>; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Maurice+T%22">Maurice T</searchLink>; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Pytka+K%22">Pytka K</searchLink>; Laboratory of Experimental Neuropharmacology, Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland. Electronic address: karolina.pytka@uj.edu.pl.
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