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Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness.

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Title: Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness.
Authors: Han X; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Skatova V; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Mikelov A; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Ji X; Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA., Hoh RA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Lee JY; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Cao S; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Seastedt H; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Schuetz J; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Fernandes A; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Singhal A; Department of Computer Science, School of Engineering, Stanford University, Stanford, CA, USA., Grubert F; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., DeKruyff RH; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Maecker HT; Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Galli SJ; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Manohar M; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Chinthrajah RS; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. schinths@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. schinths@stanford.edu., Kasowski MM; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu., Boyd SD; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu., Nadeau KC; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. knadeau@hsph.harvard.edu.; Harvard H.T. Chan School of Public Health, Boston, MA, USA. knadeau@hsph.harvard.edu.
Source: Nature immunology [Nat Immunol] 2025 Dec; Vol. 26 (12), pp. 2328-2342. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness.
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  Data: <searchLink fieldCode="AU" term="%22Han+X%22">Han X</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Skatova+V%22">Skatova V</searchLink>; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mikelov+A%22">Mikelov A</searchLink>; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ji+X%22">Ji X</searchLink>; Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hoh+RA%22">Hoh RA</searchLink>; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Seastedt+H%22">Seastedt H</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schuetz+J%22">Schuetz J</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fernandes+A%22">Fernandes A</searchLink>; Sean N. 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Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. schinths@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. schinths@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Kasowski+MM%22">Kasowski MM</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. kasowski@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Boyd+SD%22">Boyd SD</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sboyd1@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Nadeau+KC%22">Nadeau KC</searchLink>; Sean N. Parker Center for Allergy and Asthma Research, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. knadeau@hsph.harvard.edu.; Harvard H.T. Chan School of Public Health, Boston, MA, USA. knadeau@hsph.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2025 Dec; Vol. 26 (12), pp. 2328-2342. <i>Date of Electronic Publication: </i>2025 Nov 04.
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