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PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor-Resistant Chronic Lymphocytic Leukemia.

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Title: PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor-Resistant Chronic Lymphocytic Leukemia.
Authors: Gordon BK; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Muhowski EM; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio., Singh J; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Ravikrishnan J; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Peris-Cuesta A; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Diaz Rohena D; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Sanchez JR; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Thangavadivel S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Benrashid S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., He A; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Marr AR; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Mitchell AD; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio., Urrutia JM; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Misra S; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Lai TH; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Yu L; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio., Walker BR; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Perry E; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Shukla SA; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Grieselhuber NR; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Rogers KA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Lapalombella R; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Blachly JS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Kittai AS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Bhat SA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio., Jain N; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Wierda WG; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Byrd JC; Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio., Niesman M; MingSight Pharmaceuticals Inc., San Diego, California., Zhang K; MingSight Pharmaceuticals Inc., San Diego, California., Sampath D; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas., Woyach JA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
Source: Blood cancer discovery [Blood Cancer Discov] 2026 Jan 12; Vol. 7 (1), pp. 85-103.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE
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  Data: PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor-Resistant Chronic Lymphocytic Leukemia.
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Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Thangavadivel+S%22">Thangavadivel S</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Benrashid+S%22">Benrashid S</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22He+A%22">He A</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Marr+AR%22">Marr AR</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Mitchell+AD%22">Mitchell AD</searchLink>; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Urrutia+JM%22">Urrutia JM</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Misra+S%22">Misra S</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Lai+TH%22">Lai TH</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Walker+BR%22">Walker BR</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Perry+E%22">Perry E</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Shukla+SA%22">Shukla SA</searchLink>; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Grieselhuber+NR%22">Grieselhuber NR</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Rogers+KA%22">Rogers KA</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Lapalombella+R%22">Lapalombella R</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Blachly+JS%22">Blachly JS</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Kittai+AS%22">Kittai AS</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Bhat+SA%22">Bhat SA</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Jain+N%22">Jain N</searchLink>; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Wierda+WG%22">Wierda WG</searchLink>; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Byrd+JC%22">Byrd JC</searchLink>; Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Niesman+M%22">Niesman M</searchLink>; MingSight Pharmaceuticals Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; MingSight Pharmaceuticals Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Sampath+D%22">Sampath D</searchLink>; Division of Hematopoietic Biology and Malignancy, MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Woyach+JA%22">Woyach JA</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
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