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Outcomes following CD22 CAR T-cells in B-ALL: a tale of two manufacturing strategies.

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Title: Outcomes following CD22 CAR T-cells in B-ALL: a tale of two manufacturing strategies.
Authors: Dreyzin A; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Kramer AM; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA., Yates B; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Wang HW; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA., Sahaf B; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Stanford University School of Medicine, Cancer Correlative Science Unit, Stanford Cancer Institute, Stanford, California, USA., Yuan C; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA., Klysz D; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Laboratory for Cell and Gene Medicine, Stanford University, Stanford, California, USA., Tunuguntla R; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Laboratory for Cell and Gene Medicine, Stanford University, Stanford, California, USA., Ehlinger Z; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Stanford University School of Medicine, Cancer Correlative Science Unit, Stanford Cancer Institute, Stanford, California, USA., Reitberg S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA., Adebola S; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., Su A; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Ebina-Shibuya R; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Department of Medical Science and Innovation, SiRIUS Institute of Medical Research, Tohoku University, Sendai, Japan and Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan., Jia D; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., Achar S; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., Patil S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Stanford University School of Medicine, Cancer Correlative Science Unit, Stanford Cancer Institute, Stanford, California, USA., Martin K; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA., Jeyakumar N; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA., Davis KL; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA., Fry T; Department of Pediatrics and Immunology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Aurora, Colorado, USA., Mackall CL; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA., Taylor N; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Altan-Bonnet G; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., Highfill S; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA., Feldman S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Laboratory for Cell and Gene Medicine, Stanford University, Stanford, California, USA., Stroncek DF; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA., Chien C; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Schultz LM; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA., Frank MJ; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA., Muffly LS; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA., Shalabi H; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Ramakrishna S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA. Electronic address: ramakrs@stanford.edu., Shah NN; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: nirali.shah@nih.gov.
Source: Cytotherapy [Cytotherapy] 2026 Mar; Vol. 28 (3), pp. 101990. Date of Electronic Publication: 2025 Oct 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 100895309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2566 (Electronic) Linking ISSN: 14653249 NLM ISO Abbreviation: Cytotherapy Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Outcomes following CD22 CAR T-cells in B-ALL: a tale of two manufacturing strategies.
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  Data: <searchLink fieldCode="AU" term="%22Dreyzin+A%22">Dreyzin A</searchLink>; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kramer+AM%22">Kramer AM</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Yates+B%22">Yates B</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wang+HW%22">Wang HW</searchLink>; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sahaf+B%22">Sahaf B</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Stanford University School of Medicine, Cancer Correlative Science Unit, Stanford Cancer Institute, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+C%22">Yuan C</searchLink>; Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Klysz+D%22">Klysz D</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Laboratory for Cell and Gene Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Tunuguntla+R%22">Tunuguntla R</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Laboratory for Cell and Gene Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Ehlinger+Z%22">Ehlinger Z</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Stanford University School of Medicine, Cancer Correlative Science Unit, Stanford Cancer Institute, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Reitberg+S%22">Reitberg S</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Adebola+S%22">Adebola S</searchLink>; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Su+A%22">Su A</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ebina-Shibuya+R%22">Ebina-Shibuya R</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Department of Medical Science and Innovation, SiRIUS Institute of Medical Research, Tohoku University, Sendai, Japan and Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Jia+D%22">Jia D</searchLink>; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Achar+S%22">Achar S</searchLink>; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Patil+S%22">Patil S</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Stanford University School of Medicine, Cancer Correlative Science Unit, Stanford Cancer Institute, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Martin+K%22">Martin K</searchLink>; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Jeyakumar+N%22">Jeyakumar N</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Davis+KL%22">Davis KL</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Fry+T%22">Fry T</searchLink>; Department of Pediatrics and Immunology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Mackall+CL%22">Mackall CL</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+N%22">Taylor N</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Altan-Bonnet+G%22">Altan-Bonnet G</searchLink>; Immunodynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Highfill+S%22">Highfill S</searchLink>; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Feldman+S%22">Feldman S</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Laboratory for Cell and Gene Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Stroncek+DF%22">Stroncek DF</searchLink>; Center for Cellular Engineering, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chien+C%22">Chien C</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+LM%22">Schultz LM</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Frank+MJ%22">Frank MJ</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Muffly+LS%22">Muffly LS</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Shalabi+H%22">Shalabi H</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ramakrishna+S%22">Ramakrishna S</searchLink>; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, California, USA; Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, California, USA. Electronic address: ramakrs@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Shah+NN%22">Shah NN</searchLink>; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: nirali.shah@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22100895309%22">Cytotherapy</searchLink> [Cytotherapy] 2026 Mar; Vol. 28 (3), pp. 101990. <i>Date of Electronic Publication: </i>2025 Oct 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100895309 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-2566 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214653249%22">14653249 </searchLink><i>NLM ISO Abbreviation: </i>Cytotherapy <i>Subsets: </i>MEDLINE
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