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Rapid clonal selection within early hematopoietic cell compartments presages the outcome of ivosidenib combination therapy.

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Title: Rapid clonal selection within early hematopoietic cell compartments presages the outcome of ivosidenib combination therapy.
Authors: Turkalj S; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Radtke FA; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Stoilova B; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Mecklenbrauck R; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Groom AJ; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Jakobsen NA; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Lachowiez CA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Metzner M; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Usukhbayar B; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Salazar MA; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Zeng Z; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Loghavi S; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX., Marvin-Peek J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Körber V; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Ravandi F; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Issa G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Kadia T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Symeonidou V; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., de Groot AP; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom., Kantarjian H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., DiNardo CD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Vyas P; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.
Source: Blood [Blood] 2026 Feb 05; Vol. 147 (6), pp. 613-632.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: Rapid clonal selection within early hematopoietic cell compartments presages the outcome of ivosidenib combination therapy.
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  Data: <searchLink fieldCode="AU" term="%22Turkalj+S%22">Turkalj S</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Radtke+FA%22">Radtke FA</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stoilova+B%22">Stoilova B</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mecklenbrauck+R%22">Mecklenbrauck R</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Groom+AJ%22">Groom AJ</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jakobsen+NA%22">Jakobsen NA</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lachowiez+CA%22">Lachowiez CA</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Metzner+M%22">Metzner M</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Usukhbayar+B%22">Usukhbayar B</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Salazar+MA%22">Salazar MA</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zeng+Z%22">Zeng Z</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Loghavi+S%22">Loghavi S</searchLink>; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Marvin-Peek+J%22">Marvin-Peek J</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Körber+V%22">Körber V</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ravandi+F%22">Ravandi F</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Issa+G%22">Issa G</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Kadia+T%22">Kadia T</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Symeonidou+V%22">Symeonidou V</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22de+Groot+AP%22">de Groot AP</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kantarjian+H%22">Kantarjian H</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Takahashi+K%22">Takahashi K</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Konopleva+M%22">Konopleva M</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22DiNardo+CD%22">DiNardo CD</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Vyas+P%22">Vyas P</searchLink>; Medical Research Council Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.
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