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Spatial single-cell atlas reveals regional variations in healthy and diseased human lung.

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Title: Spatial single-cell atlas reveals regional variations in healthy and diseased human lung.
Authors: Firsova AB; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Marco Salas S; Science for Life Laboratory, Stockholm, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Kuemmerle LB; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany., Abalo XM; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden., Sountoulidis A; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Larsson L; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden., Mahbubani KT; Department of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Theelke J; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Andrusivova Z; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden., Alonso Galicia L; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden., Liontos A; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Balassa T; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary., Kovacs F; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.; Single-Cell Technologies Ltd, Szeged, Hungary., Horvath P; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.; Single-Cell Technologies Ltd, Szeged, Hungary.; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Chen Y; Research Unit for Precision Regenerative Medicine (PRM), Helmholtz Munich, Neuherberg, Germany.; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany., Gote-Schniering J; Department of Rheumatology and Immunology and Department of Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Stoleriu MG; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Center for Thoracic Surgery Munich, University Hospital of the Ludwig-Maximilians University (LMU), Munich, Germany.; Asklepios Medical Center, Gauting, Germany.; Institute of Lung Health and Immunity, Helmholtz Munich, Neuherberg, Germany., Behr J; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Lung Health and Immunity, Helmholtz Munich, Neuherberg, Germany.; Department of Medicine V, University Hospital of the Ludwig-Maximilians University (LMU), Member of the German Center for Lung Research (DZL), Munich, Germany., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Timens W; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands., Schiller HB; Research Unit for Precision Regenerative Medicine (PRM), Helmholtz Munich, Neuherberg, Germany.; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, University Hospital of the Ludwig-Maximilians University (LMU), Munich, Germany., Luecken MD; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Lung Health and Immunity, Helmholtz Munich, Neuherberg, Germany., Theis FJ; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.; School of Computation, Information and Technology, Technical University of Munich, Munich, Germany., Lundeberg J; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden., Nilsson M; Science for Life Laboratory, Stockholm, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Nawijn MC; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands., Samakovlis C; Science for Life Laboratory, Stockholm, Sweden. christos.samakovlis@su.se.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. christos.samakovlis@su.se.; Department of Internal Medicine, Molecular Pneumology, ECCPS, Justus Liebig University, Member of the German Center for Lung Research (DZL), Giessen, Germany. christos.samakovlis@su.se.
Source: Nature communications [Nat Commun] 2025 Nov 05; Vol. 16 (1), pp. 9745. Date of Electronic Publication: 2025 Nov 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatial single-cell atlas reveals regional variations in healthy and diseased human lung.
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  Data: <searchLink fieldCode="AU" term="%22Firsova+AB%22">Firsova AB</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Marco+Salas+S%22">Marco Salas S</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kuemmerle+LB%22">Kuemmerle LB</searchLink>; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Abalo+XM%22">Abalo XM</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sountoulidis+A%22">Sountoulidis A</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Larsson+L%22">Larsson L</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Mahbubani+KT%22">Mahbubani KT</searchLink>; Department of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Theelke+J%22">Theelke J</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Andrusivova+Z%22">Andrusivova Z</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Alonso+Galicia+L%22">Alonso Galicia L</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Liontos+A%22">Liontos A</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Balassa+T%22">Balassa T</searchLink>; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Kovacs+F%22">Kovacs F</searchLink>; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.; Single-Cell Technologies Ltd, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Horvath+P%22">Horvath P</searchLink>; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.; Single-Cell Technologies Ltd, Szeged, Hungary.; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Research Unit for Precision Regenerative Medicine (PRM), Helmholtz Munich, Neuherberg, Germany.; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gote-Schniering+J%22">Gote-Schniering J</searchLink>; Department of Rheumatology and Immunology and Department of Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stoleriu+MG%22">Stoleriu MG</searchLink>; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Center for Thoracic Surgery Munich, University Hospital of the Ludwig-Maximilians University (LMU), Munich, Germany.; Asklepios Medical Center, Gauting, Germany.; Institute of Lung Health and Immunity, Helmholtz Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Behr+J%22">Behr J</searchLink>; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Lung Health and Immunity, Helmholtz Munich, Neuherberg, Germany.; Department of Medicine V, University Hospital of the Ludwig-Maximilians University (LMU), Member of the German Center for Lung Research (DZL), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+KB%22">Meyer KB</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Timens+W%22">Timens W</searchLink>; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schiller+HB%22">Schiller HB</searchLink>; Research Unit for Precision Regenerative Medicine (PRM), Helmholtz Munich, Neuherberg, Germany.; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, University Hospital of the Ludwig-Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Luecken+MD%22">Luecken MD</searchLink>; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Lung Health and Immunity, Helmholtz Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Theis+FJ%22">Theis FJ</searchLink>; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.; School of Computation, Information and Technology, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lundeberg+J%22">Lundeberg J</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Gene Technology, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Nilsson+M%22">Nilsson M</searchLink>; Science for Life Laboratory, Stockholm, Sweden.; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Nawijn+MC%22">Nawijn MC</searchLink>; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Samakovlis+C%22">Samakovlis C</searchLink>; Science for Life Laboratory, Stockholm, Sweden. christos.samakovlis@su.se.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. christos.samakovlis@su.se.; Department of Internal Medicine, Molecular Pneumology, ECCPS, Justus Liebig University, Member of the German Center for Lung Research (DZL), Giessen, Germany. christos.samakovlis@su.se.
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