Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology.
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| Title: | Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology. |
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| Authors: | Burger D; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland., Kashyrina M; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.; Laboratory of Human Anatomy, Department of Experimental Medicine, Univ. Salento, Lecce, Italy., van den Heuvel L; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland., de La Seiglière H; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Lewis AJ; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland., De Nuccio F; Laboratory of Human Anatomy, Department of Experimental Medicine, Univ. Salento, Lecce, Italy., Mohammed I; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland.; Dubochet Center for Imaging, Lausanne, Genopode (UNIL), EPFL, Lausanne, Switzerland., Verchère J; Neurodegenerative Diseases Unit, ANSES, Univ. Lyon, Lyon, France., Feuillie C; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France., Berbon M; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France., Arotcarena ML; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Retailleau A; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Bezard E; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Canron MH; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Meissner WG; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France.; Service de Neurologie des Maladies Neurodégénératives, IMNc, CHU Bordeaux, Bordeaux, France., Loquet A; Institut de Chimie et Biologie des Membranes et des Nano-objets, UMR 5248, Univ. Bordeaux, CNRS, Bordeaux INP, Pessac, France., Bousset L; Laboratoire des Maladies Neurodégénératives, UMR 9199, Univ. Paris-Saclay, CNRS, CEA, Fontenay-aux-Roses, France., Poujol C; Bordeaux Imaging Center, UAR 3420, US 4, Univ. Bordeaux, CNRS, INSERM, Bordeaux, France., Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden., Laferrière F; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Baron T; Neurodegenerative Diseases Unit, ANSES, Univ. Lyon, Lyon, France., Lofrumento DD; Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, Univ. Salento, Lecce, Italy., De Giorgi F; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France., Stahlberg H; Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Science, EPFL, Lausanne, Switzerland. henning.stahlberg@epfl.ch.; Department of Fundamental Microbiology, Faculty of Biology and Medicine, UNIL, Lausanne, Switzerland. henning.stahlberg@epfl.ch., Ichas F; Institut des Maladies Neurodégénératives, UMR 5293, Univ. Bordeaux, CNRS, Bordeaux, France. francois.ichas@inserm.fr.; Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, Univ. Salento, Lecce, Italy. francois.ichas@inserm.fr. |
| Source: | Nature [Nature] 2025 Dec; Vol. 648 (8093), pp. 409-417. Date of Electronic Publication: 2025 Nov 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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