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Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial.

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Title: Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial.
Authors: Xue L; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.)., Bhattacharya R; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.).; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.).; Department of Medicine, Harvard Medical School, Boston, MA (R. Bhattacharya, A.P., P.L., P.N.)., Uddin MM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.)., Nakao T; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.).; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Zou R; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Patel A; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.).; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.).; Department of Medicine, Harvard Medical School, Boston, MA (R. Bhattacharya, A.P., P.L., P.N.)., Haidermota S; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Niroula A; Cancer Program, Broad Institute, Cambridge, MA (A.N.).; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Sweden (A.N.).; SciLifeLab, University of Gothenburg, Sweden (A.N.)., Viscosi V; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Postupaka D; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Bhatnagar A; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.).; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Finneran P; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Bernardo R; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.).; George Washington University School of Medicine and Health Sciences, Washington, DC (R. Bernardo)., Diggs MR; Metabolism Unit (M.R.D., K.V.F., S.M. C., S.M., M.V.Z., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston., Fitch KV; Metabolism Unit (M.R.D., K.V.F., S.M. C., S.M., M.V.Z., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston., Chu SM; Metabolism Unit (M.R.D., K.V.F., S.M. C., S.M., M.V.Z., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston., McCallum S; Metabolism Unit (M.R.D., K.V.F., S.M. C., S.M., M.V.Z., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston., Currier JS; Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles (J.S.C.)., Fichtenbaum CJ; Division of Infectious Diseases, University of Cincinnati College of Medicine, OH (C.J.F.)., Malvestutto CD; Division of Infectious Diseases, Ohio State University Medical Center, Columbus (C.D.M.)., Aberg JA; Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY (J.A.A.)., Bloomfield GS; Department of Medicine, Duke Global Health Institute and Duke Clinical Research Institute, Duke University, Durham, NC (G.S.B.)., Ribaudo HJ; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA (H.J.R.)., Zanni MV; Metabolism Unit (M.R.D., K.V.F., S.M. C., S.M., M.V.Z., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston., Libby P; Department of Medicine, Harvard Medical School, Boston, MA (R. Bhattacharya, A.P., P.L., P.N.).; Division of Cardiology, Brigham and Women's Hospital, Boston, MA (P.L.)., Hornsby W; Cardiovascular Research Center and Center for Genomic Medicine, Metabolism Unit, Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston (R. Bhattacharya, T.N., R.Z., A.P., S.H., V.V., D.P., A.B., P.F., R. Bernardo, W.H., P.N.)., Lu MT; Department of Radiology, Cardiovascular Imaging Research Center (M.T.L.), Massachusetts General Hospital and Harvard Medical School, Boston., Douglas PS; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.)., Grinspoon SK; Metabolism Unit (M.R.D., K.V.F., S.M. C., S.M., M.V.Z., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston., Natarajan P; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (L.X., R. Bhattacharya, M.M.U., T.N., A.P., A.B., P.N.).; Department of Medicine, Harvard Medical School, Boston, MA (R. Bhattacharya, A.P., P.L., P.N.).
Source: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2026 Jan; Vol. 46 (1), pp. 168-177. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Research Support, N.I.H., Extramural
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE
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  Data: Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial.
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