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Safety and tolerability of Rinvecalinase Alfa (DM199) for acute ischemic stroke (ReMEDy1).

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Title: Safety and tolerability of Rinvecalinase Alfa (DM199) for acute ischemic stroke (ReMEDy1).
Authors: Campbell BC; Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.; Department of Neurology, The Royal Melbourne Hospital, Parkville, VIC, Australia., Kasner SE; Division of Vascular Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., Lista AD; DiaMedica Therapeutics Inc., Minnetonka, MN, USA., Volpi JJ; The Houston Methodist Institute for Academic Medicine, Houston, TX, USA., Kleinig TJ; Department of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australia., Cordato D; Department of Neurology, Liverpool Hospital, Liverpool, NSW, Australia., Dewey HM; Department of Neurosciences, Eastern Health and Eastern Health Clinical School, Monash University, Box Hill, VIC, Australia., Choi PM; Department of Neurosciences, Eastern Health and Eastern Health Clinical School, Monash University, Box Hill, VIC, Australia., Garcia-Esperon C; Department of Neurology, Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia., Sahathevan R; Deakin University and St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia., Wijeratne T; Department of Medicine and Neurology, Melbourne Medical School, The University of Melbourne and Western Health, Sunshine Hospital, St Albans, VIC, Australia., Wong AA; Department of Neurology, Royal Brisbane and Women's Hospital and the University of Queensland, Brisbane, QLD, Australia., Ghia D; Fiona Stanley Hospital, Perth, WA, Australia., Cloud GC; Department of Neuroscience, Alfred Hospital, Prahran, Victoria and Department of Neuroscience, School of Translational Medicine, Momash University, Melbourne, VIC, Australia., Giuffre M; University of Calgary, Departments of Pediatrics and Cardiology, Libin Cardiovascular Institute, Calgary, AB, Canada., Bath PM; Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Corporate Authors: ReMEDy1 Investigators
Source: International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2026 Jul; Vol. 21 (6), pp. 861-870. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and tolerability of Rinvecalinase Alfa (DM199) for acute ischemic stroke (ReMEDy1).
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  Data: <searchLink fieldCode="AU" term="%22Campbell+BC%22">Campbell BC</searchLink>; Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.; Department of Neurology, The Royal Melbourne Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kasner+SE%22">Kasner SE</searchLink>; Division of Vascular Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lista+AD%22">Lista AD</searchLink>; DiaMedica Therapeutics Inc., Minnetonka, MN, USA.<br /><searchLink fieldCode="AU" term="%22Volpi+JJ%22">Volpi JJ</searchLink>; The Houston Methodist Institute for Academic Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kleinig+TJ%22">Kleinig TJ</searchLink>; Department of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Cordato+D%22">Cordato D</searchLink>; Department of Neurology, Liverpool Hospital, Liverpool, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dewey+HM%22">Dewey HM</searchLink>; Department of Neurosciences, Eastern Health and Eastern Health Clinical School, Monash University, Box Hill, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Choi+PM%22">Choi PM</searchLink>; Department of Neurosciences, Eastern Health and Eastern Health Clinical School, Monash University, Box Hill, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Garcia-Esperon+C%22">Garcia-Esperon C</searchLink>; Department of Neurology, Priority Research Centre for Brain and Mental Health Research, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sahathevan+R%22">Sahathevan R</searchLink>; Deakin University and St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wijeratne+T%22">Wijeratne T</searchLink>; Department of Medicine and Neurology, Melbourne Medical School, The University of Melbourne and Western Health, Sunshine Hospital, St Albans, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+AA%22">Wong AA</searchLink>; Department of Neurology, Royal Brisbane and Women's Hospital and the University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Ghia+D%22">Ghia D</searchLink>; Fiona Stanley Hospital, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Cloud+GC%22">Cloud GC</searchLink>; Department of Neuroscience, Alfred Hospital, Prahran, Victoria and Department of Neuroscience, School of Translational Medicine, Momash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Giuffre+M%22">Giuffre M</searchLink>; University of Calgary, Departments of Pediatrics and Cardiology, Libin Cardiovascular Institute, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Bath+PM%22">Bath PM</searchLink>; Stroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK.
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  Data: <searchLink fieldCode="JN" term="%22101274068%22">International journal of stroke : official journal of the International Stroke Society</searchLink> [Int J Stroke] 2026 Jul; Vol. 21 (6), pp. 861-870. <i>Date of Electronic Publication: </i>2025 Nov 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274068 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1747-4949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217474930%22">17474930 </searchLink><i>NLM ISO Abbreviation: </i>Int J Stroke <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul
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