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Studies addressing potential bioactivation and genotoxicity liabilities of the N-nitroso derivative of the antidepressant paroxetine.

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Title: Studies addressing potential bioactivation and genotoxicity liabilities of the N-nitroso derivative of the antidepressant paroxetine.
Authors: Heck CJS; Pfizer Research and Development, Groton, CT, USA., Eng H; Pfizer Research and Development, Groton, CT, USA., Cheung JR; Pfizer Research and Development, Groton, CT, USA., Tillotson J; Pfizer Research and Development, Cambridge, MA, USA., Dobo KL; Pfizer Research and Development, Groton, CT, USA., Kalgutkar AS; Pfizer Research and Development, Cambridge, MA, USA.
Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2025 Oct; Vol. 55 (10), pp. 737-752. Date of Electronic Publication: 2025 Nov 18.
Publication Type: Journal Article
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
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AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Studies addressing potential bioactivation and genotoxicity liabilities of the N-nitroso derivative of the antidepressant paroxetine.
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  Data: <searchLink fieldCode="AU" term="%22Heck+CJS%22">Heck CJS</searchLink>; Pfizer Research and Development, Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Eng+H%22">Eng H</searchLink>; Pfizer Research and Development, Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Cheung+JR%22">Cheung JR</searchLink>; Pfizer Research and Development, Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Tillotson+J%22">Tillotson J</searchLink>; Pfizer Research and Development, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dobo+KL%22">Dobo KL</searchLink>; Pfizer Research and Development, Groton, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kalgutkar+AS%22">Kalgutkar AS</searchLink>; Pfizer Research and Development, Cambridge, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%221306665%22">Xenobiotica; the fate of foreign compounds in biological systems</searchLink> [Xenobiotica] 2025 Oct; Vol. 55 (10), pp. 737-752. <i>Date of Electronic Publication: </i>2025 Nov 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Informa+Healthcare%22">Informa Healthcare </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>1306665 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1366-5928 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200498254%22">00498254 </searchLink><i>NLM ISO Abbreviation: </i>Xenobiotica <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41196116
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        Value: 10.1080/00498254.2025.2586614
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      – Code: eng
        Text: English
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        StartPage: 737
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      – TitleFull: Studies addressing potential bioactivation and genotoxicity liabilities of the N-nitroso derivative of the antidepressant paroxetine.
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            NameFull: Eng H
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              M: 10
              Text: 2025 Oct
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              Y: 2025
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            – TitleFull: Xenobiotica; the fate of foreign compounds in biological systems
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