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Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.

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Title: Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.
Authors: Suresh S; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada., Shaw AL; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada., Akintola DK; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada., Lunke M; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada., Doerr S; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA; Department of Biology, University of Oregon, Eugene, Oregon, USA., Rohilla P; Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA., Balla T; Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA., Yip CK; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada., Hansen SD; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA., Cobb JA; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada; University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada. Electronic address: jeburke@uvic.ca.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Dec; Vol. 301 (12), pp. 110886. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.
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  Data: <searchLink fieldCode="AU" term="%22Suresh+S%22">Suresh S</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Shaw+AL%22">Shaw AL</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Akintola+DK%22">Akintola DK</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Lunke+M%22">Lunke M</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Doerr+S%22">Doerr S</searchLink>; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA; Department of Biology, University of Oregon, Eugene, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Rohilla+P%22">Rohilla P</searchLink>; Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Balla+T%22">Balla T</searchLink>; Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Yip+CK%22">Yip CK</searchLink>; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Hansen+SD%22">Hansen SD</searchLink>; Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA; Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Cobb+JA%22">Cobb JA</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Burke+JE%22">Burke JE</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada; University of Victoria Genome BC Proteomics Centre, Victoria, British Columbia, Canada. Electronic address: jeburke@uvic.ca.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Dec; Vol. 301 (12), pp. 110886. <i>Date of Electronic Publication: </i>2025 Nov 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2025.110886
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              Text: 2025 Dec
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