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Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.

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Title: Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.
Authors: Wu C; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States., Meuser ME; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States., Rey JS; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States., Meshkin H; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States., Yang R; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States., Devarkar SC; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States., Freniere C; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States., Shi J; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States., Aiken C; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States., Perilla JR; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Nov 19; Vol. 147 (46), pp. 42685-42700. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
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  Data: Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.
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  Data: <searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.<br /><searchLink fieldCode="AU" term="%22Meuser+ME%22">Meuser ME</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.<br /><searchLink fieldCode="AU" term="%22Rey+JS%22">Rey JS</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.<br /><searchLink fieldCode="AU" term="%22Meshkin+H%22">Meshkin H</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.<br /><searchLink fieldCode="AU" term="%22Devarkar+SC%22">Devarkar SC</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.<br /><searchLink fieldCode="AU" term="%22Freniere+C%22">Freniere C</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Aiken+C%22">Aiken C</searchLink>; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Perilla+JR%22">Perilla JR</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States.
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              Text: 2025 Nov 19
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