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PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.

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Title: PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.
Authors: Huber AD; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Lin W; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Jung YH; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Poudel S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Carrigan AG; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pagala V; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang W; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Fu Y; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yuan ZF; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Byrum SD; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang K; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gee RRF; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Arnold ED; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Loughran AJ; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. taosheng.chen@stjude.org.
Source: Nature communications [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9805. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.
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  Data: <searchLink fieldCode="AU" term="%22Huber+AD%22">Huber AD</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lin+W%22">Lin W</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jung+YH%22">Jung YH</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Poudel+S%22">Poudel S</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+G%22">Yang G</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Carrigan+AG%22">Carrigan AG</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pagala+V%22">Pagala V</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+ZF%22">Yuan ZF</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Byrum+SD%22">Byrum SD</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gee+RRF%22">Gee RRF</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+ED%22">Arnold ED</searchLink>; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Loughran+AJ%22">Loughran AJ</searchLink>; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pruett-Miller+SM%22">Pruett-Miller SM</searchLink>; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. taosheng.chen@stjude.org.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9805. <i>Date of Electronic Publication: </i>2025 Nov 06.
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