View in EDS HTML Full Text PDF Full Text

A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.

Saved in:
Bibliographic Details
Title: A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.
Authors: Urem M; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.; Centre for Microbial Cell Biology, Leiden, The Netherlands., Friggen AH; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands., Musch N; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands., Silverman MH; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Swain CJ; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Barbachyn MR; Calvin University, Grand Rapids, MI, USA., Mortin LI; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Yu X; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., DeLuccia RJ; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Lamers MH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands. m.h.lamers@lumc.nl.; NeCEN-Netherlands Centre For Electron Nanoscopy, Leiden, The Netherlands. m.h.lamers@lumc.nl., Smits WK; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands. w.k.smits@lumc.nl.; Centre for Microbial Cell Biology, Leiden, The Netherlands. w.k.smits@lumc.nl.
Source: Nature communications [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9784. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41198680
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Urem+M%22">Urem M</searchLink>; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.; Centre for Microbial Cell Biology, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Friggen+AH%22">Friggen AH</searchLink>; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Musch+N%22">Musch N</searchLink>; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Silverman+MH%22">Silverman MH</searchLink>; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA.<br /><searchLink fieldCode="AU" term="%22Swain+CJ%22">Swain CJ</searchLink>; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA.<br /><searchLink fieldCode="AU" term="%22Barbachyn+MR%22">Barbachyn MR</searchLink>; Calvin University, Grand Rapids, MI, USA.<br /><searchLink fieldCode="AU" term="%22Mortin+LI%22">Mortin LI</searchLink>; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA.<br /><searchLink fieldCode="AU" term="%22DeLuccia+RJ%22">DeLuccia RJ</searchLink>; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lamers+MH%22">Lamers MH</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands. m.h.lamers@lumc.nl.; NeCEN-Netherlands Centre For Electron Nanoscopy, Leiden, The Netherlands. m.h.lamers@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Smits+WK%22">Smits WK</searchLink>; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands. w.k.smits@lumc.nl.; Centre for Microbial Cell Biology, Leiden, The Netherlands. w.k.smits@lumc.nl.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9784. <i>Date of Electronic Publication: </i>2025 Nov 06.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41198680
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-025-65324-8
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 9784
    Titles:
      – TitleFull: A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Urem M
      – PersonEntity:
          Name:
            NameFull: Friggen AH
      – PersonEntity:
          Name:
            NameFull: Musch N
      – PersonEntity:
          Name:
            NameFull: Silverman MH
      – PersonEntity:
          Name:
            NameFull: Swain CJ
      – PersonEntity:
          Name:
            NameFull: Barbachyn MR
      – PersonEntity:
          Name:
            NameFull: Mortin LI
      – PersonEntity:
          Name:
            NameFull: Yu X
      – PersonEntity:
          Name:
            NameFull: DeLuccia RJ
      – PersonEntity:
          Name:
            NameFull: Lamers MH
      – PersonEntity:
          Name:
            NameFull: Smits WK
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 06
              M: 11
              Text: 2025 Nov 06
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1