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Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.

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Title: Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.
Authors: Ferrari-Souza JP; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Povala G; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Rahmouni N; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Bellaver B; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ferreira PCL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., De Bastiani MA; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Leffa DT; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lussier FZ; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Aguzzoli CS; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Brain Institute of Rio Grande do Sul, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Brum WS; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Carello-Collar G; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Borelli WV; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Morphological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Hospital Moinhos de Vento, Porto Alegre, Brazil., Therriault J; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Macedo AC; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Servaes S; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Stevenson J; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Pola I; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Gauthier S; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Souza DO; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Schilling LP; Brain Institute of Rio Grande do Sul, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Lourenco MV; Institute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Triana-Baltzer G; Precision Measures, Johnson & Johnson, La Jolla, CA, USA., Kolb HC; Enigma Biomedical Group, Knoxville, TN, USA.; Department of Medical Physics, University of Wisconsin, Madison, WI, USA., Benedet AL; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Ashton NJ; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Banner Alzheimer's Institute and University of Arizona, Phoenix, AZ, USA.; Banner Sun Health Research Institute, Sun City, AZ, USA., Tudorascu DL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Blennow K; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China., Johnson SC; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Pascoal TA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Rosa-Neto P; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.; Peter O'Donnell Jr Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX, USA. pedro.rosa@mcgill.ca., Zimmer ER; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. eduardo.zimmer@hmv.org.br.; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. eduardo.zimmer@hmv.org.br.; Hospital Moinhos de Vento, Porto Alegre, Brazil. eduardo.zimmer@hmv.org.br.; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada. eduardo.zimmer@hmv.org.br.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. eduardo.zimmer@hmv.org.br.
Source: Nature neuroscience [Nat Neurosci] 2026 Jan; Vol. 29 (1), pp. 81-87. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Ferrari-Souza+JP%22">Ferrari-Souza JP</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Povala+G%22">Povala G</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rahmouni+N%22">Rahmouni N</searchLink>; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Bellaver+B%22">Bellaver B</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+PCL%22">Ferreira PCL</searchLink>; 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Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Gauthier+S%22">Gauthier S</searchLink>; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Souza+DO%22">Souza DO</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Schilling+LP%22">Schilling LP</searchLink>; Brain Institute of Rio Grande do Sul, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Lourenco+MV%22">Lourenco MV</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Triana-Baltzer+G%22">Triana-Baltzer G</searchLink>; Precision Measures, Johnson & Johnson, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kolb+HC%22">Kolb HC</searchLink>; Enigma Biomedical Group, Knoxville, TN, USA.; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Benedet+AL%22">Benedet AL</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Ashton+NJ%22">Ashton NJ</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Banner Alzheimer's Institute and University of Arizona, Phoenix, AZ, USA.; Banner Sun Health Research Institute, Sun City, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Pascoal+TA%22">Pascoal TA</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.; Peter O'Donnell Jr Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX, USA. pedro.rosa@mcgill.ca.<br /><searchLink fieldCode="AU" term="%22Zimmer+ER%22">Zimmer ER</searchLink>; 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