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Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.

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Title: Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.
Authors: Domingues N; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. neuza.domingues@uc.pt., Calcagni' A; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Translational Medical Sciences, Federico II University, Naples, Italy., Freire S; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Pires J; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Casqueiro R; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Salazar IL; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Herz NJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Huynh T; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Wieciorek K; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany., Outeiro TF; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany., Girão H; Coimbra Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology, Academic and Clinical Center of Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Milosevic I; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ballabio A; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Translational Medical Sciences, Federico II University, Naples, Italy.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.; SSM School for Advanced Studies, Federico II University, Naples, Italy., Raimundo N; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. nuno.raimundo@psu.edu.; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA. nuno.raimundo@psu.edu.; Penn State Cancer Institute, Hershey, PA, USA. nuno.raimundo@psu.edu.
Source: EMBO reports [EMBO Rep] 2025 Dec; Vol. 26 (24), pp. 6096-6120. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.
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  Data: <searchLink fieldCode="AU" term="%22Domingues+N%22">Domingues N</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. neuza.domingues@uc.pt.<br /><searchLink fieldCode="AU" term="%22Calcagni'+A%22">Calcagni' A</searchLink>; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Translational Medical Sciences, Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Freire+S%22">Freire S</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Pires+J%22">Pires J</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Casqueiro+R%22">Casqueiro R</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Salazar+IL%22">Salazar IL</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Herz+NJ%22">Herz NJ</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huynh+T%22">Huynh T</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wieciorek+K%22">Wieciorek K</searchLink>; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Outeiro+TF%22">Outeiro TF</searchLink>; University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Girão+H%22">Girão H</searchLink>; Coimbra Institute for Clinical and Biomedical Research (iCBR), Centre for Innovative Biomedicine and Biotechnology, Academic and Clinical Center of Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Milosevic+I%22">Milosevic I</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ballabio+A%22">Ballabio A</searchLink>; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Translational Medical Sciences, Federico II University, Naples, Italy.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.; SSM School for Advanced Studies, Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Raimundo+N%22">Raimundo N</searchLink>; Multidisciplinary Institute of Ageing, Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. nuno.raimundo@psu.edu.; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA. nuno.raimundo@psu.edu.; Penn State Cancer Institute, Hershey, PA, USA. nuno.raimundo@psu.edu.
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