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Combination of the Novel RAF Dimer Inhibitor Brimarafenib With the MEK Inhibitor Mirdametinib Is Effective Against NRAS Mutant Melanoma.

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Title: Combination of the Novel RAF Dimer Inhibitor Brimarafenib With the MEK Inhibitor Mirdametinib Is Effective Against NRAS Mutant Melanoma.
Authors: Tellenbach FL; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Seiler L; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Johnson M; SpringWorks Therapeutics, Stamford, Connecticut, USA., Rehrauer H; Functional Genomics Center Zurich, University of Zurich, Zurich, Switzerland., Schukla P; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Martinez-Gomez J; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Stoffel CI; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Kamal A; SpringWorks Therapeutics, Stamford, Connecticut, USA., Dummer R; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Levesque MP; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland., Eichhoff OM; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Source: Pigment cell & melanoma research [Pigment Cell Melanoma Res] 2025 Nov; Vol. 38 (6), pp. e70062.
Publication Type: Journal Article
Journal Info: Publisher: Blackwell Munksgaard Country of Publication: England NLM ID: 101318927 Publication Model: Print Cited Medium: Internet ISSN: 1755-148X (Electronic) Linking ISSN: 17551471 NLM ISO Abbreviation: Pigment Cell Melanoma Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combination of the Novel RAF Dimer Inhibitor Brimarafenib With the MEK Inhibitor Mirdametinib Is Effective Against NRAS Mutant Melanoma.
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  Data: <searchLink fieldCode="AU" term="%22Tellenbach+FL%22">Tellenbach FL</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seiler+L%22">Seiler L</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Johnson+M%22">Johnson M</searchLink>; SpringWorks Therapeutics, Stamford, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Rehrauer+H%22">Rehrauer H</searchLink>; Functional Genomics Center Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schukla+P%22">Schukla P</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Martinez-Gomez+J%22">Martinez-Gomez J</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stoffel+CI%22">Stoffel CI</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kamal+A%22">Kamal A</searchLink>; SpringWorks Therapeutics, Stamford, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Dummer+R%22">Dummer R</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Levesque+MP%22">Levesque MP</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Eichhoff+OM%22">Eichhoff OM</searchLink>; Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Blackwell+Munksgaard%22">Blackwell Munksgaard </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101318927 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1755-148X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217551471%22">17551471 </searchLink><i>NLM ISO Abbreviation: </i>Pigment Cell Melanoma Res <i>Subsets: </i>MEDLINE
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              Text: 2025 Nov
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