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ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer.

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Title: ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer.
Authors: Bonechi F; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Bacci M; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Lorito N; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Smiriglia A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Subbiani A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Pagliantini E; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Comito G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Gangarossa G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Duatti A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., El Botty R; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Sourd L; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Romano E; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Tani G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Segatto I; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy., Belletti B; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy., Meattini I; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Livi L; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Cerbelli B; Department of Medico-Surgical Sciences and Biotechnologies, Policlinico Umberto I University Hospital, Sapienza University of Rome, Rome, Italy., Botticelli A; UOC Oncologia A, Department of Hematology, Oncology and Dermatology, Policlinico Umberto I University Hospital, Sapienza University of Rome, Rome, Italy., Fiorillo M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy., Marangoni E; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Morandi A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Source: Cancer research [Cancer Res] 2026 Feb 02; Vol. 86 (3), pp. 679-692.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Bonechi+F%22">Bonechi F</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bacci+M%22">Bacci M</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Lorito+N%22">Lorito N</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Smiriglia+A%22">Smiriglia A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Subbiani+A%22">Subbiani A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Pagliantini+E%22">Pagliantini E</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Comito+G%22">Comito G</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Gangarossa+G%22">Gangarossa G</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Duatti+A%22">Duatti A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22El+Botty+R%22">El Botty R</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sourd+L%22">Sourd L</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Romano+E%22">Romano E</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Tani+G%22">Tani G</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Segatto+I%22">Segatto I</searchLink>; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Belletti+B%22">Belletti B</searchLink>; Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, National Cancer Institute, Aviano, Italy.<br /><searchLink fieldCode="AU" term="%22Meattini+I%22">Meattini I</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Livi+L%22">Livi L</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Cerbelli+B%22">Cerbelli B</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, Policlinico Umberto I University Hospital, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Botticelli+A%22">Botticelli A</searchLink>; UOC Oncologia A, Department of Hematology, Oncology and Dermatology, Policlinico Umberto I University Hospital, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fiorillo+M%22">Fiorillo M</searchLink>; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.<br /><searchLink fieldCode="AU" term="%22Marangoni+E%22">Marangoni E</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Morandi+A%22">Morandi A</searchLink>; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 02
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