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Loss of ADAM17 in smooth muscle cells enhances their transformation to macrophage-like cells leading to more severe atherosclerosis in mice.

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Title: Loss of ADAM17 in smooth muscle cells enhances their transformation to macrophage-like cells leading to more severe atherosclerosis in mice.
Authors: Meganathan I; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Kilic T; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Al Rimon R; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Naiya T; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Krishnan V; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Atanasova N; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Wong A; University Health Network, Department of Immunology, University of Toronto, Toronto, ON, Canada; Ted Rogers Centre for Heart Research at the Peter Munk Cardiac Centre, Canada., Oudit GY; Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Epelman S; University Health Network, Department of Immunology, University of Toronto, Toronto, ON, Canada; Ted Rogers Centre for Heart Research at the Peter Munk Cardiac Centre, Canada., Kassiri Z; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. Electronic address: z.kassiri@ualberta.ca.
Source: Atherosclerosis [Atherosclerosis] 2025 Dec; Vol. 411, pp. 120567. Date of Electronic Publication: 2025 Oct 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of ADAM17 in smooth muscle cells enhances their transformation to macrophage-like cells leading to more severe atherosclerosis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Meganathan+I%22">Meganathan I</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Kilic+T%22">Kilic T</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Al+Rimon+R%22">Al Rimon R</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Naiya+T%22">Naiya T</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Krishnan+V%22">Krishnan V</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Atanasova+N%22">Atanasova N</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+A%22">Wong A</searchLink>; University Health Network, Department of Immunology, University of Toronto, Toronto, ON, Canada; Ted Rogers Centre for Heart Research at the Peter Munk Cardiac Centre, Canada.<br /><searchLink fieldCode="AU" term="%22Oudit+GY%22">Oudit GY</searchLink>; Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Epelman+S%22">Epelman S</searchLink>; University Health Network, Department of Immunology, University of Toronto, Toronto, ON, Canada; Ted Rogers Centre for Heart Research at the Peter Munk Cardiac Centre, Canada.<br /><searchLink fieldCode="AU" term="%22Kassiri+Z%22">Kassiri Z</searchLink>; Department of Physiology, Cardiovascular Research Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. Electronic address: z.kassiri@ualberta.ca.
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  Data: <searchLink fieldCode="JN" term="%220242543%22">Atherosclerosis</searchLink> [Atherosclerosis] 2025 Dec; Vol. 411, pp. 120567. <i>Date of Electronic Publication: </i>2025 Oct 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>0242543 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1484 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219150%22">00219150 </searchLink><i>NLM ISO Abbreviation: </i>Atherosclerosis <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.atherosclerosis.2025.120567
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        Text: English
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              Text: 2025 Dec
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