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Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial.

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Title: Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial.
Authors: Kougias P; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York., Sharath SE; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York., Zhan M; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland., Carson JL; Division of General Internal Medicine, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey., Norman LE; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland., Mi Z; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland., Pal R; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland., Dosluoglu H; Operative Care Line, VA Western NY Healthcare System, Division of Vascular Surgery, Department of Surgery, State University of New York at Buffalo., Modrall JG; Operative Care Line, Dallas VA Medical Center, Division of Vascular Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas., Sarosi GA Jr; Operative Care Line, Malcolm Randall Veterans Affairs Medical Center, Department of Surgery, University of Florida College of Medicine, Gainesville., Nelson P; Division of Vascular Surgery, Department of Surgery, University of Oklahoma School of Community Medicine, Tulsa., Arya S; Operative Care Line, Palo Alto VA Medical Center, Division of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Vascular Section, Surgery Service Line, Palo Alto, California., Scrymgeour A; Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico., Ollison J; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York., Calais LA; Cooperative Studies Program Site Monitoring, Auditing, and Resource Team, Albuquerque, New Mexico., Nambi V; Michael E. DeBakey VA Medical Center, Department of Medicine-Cardiology, Baylor College of Medicine, Houston, Texas., Gregg LP; Michael E. DeBakey VA Medical Center, VA Health Systems Research and Development Center for Innovations in Quality, Effectiveness and Safety, Department of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas., Abdullah SM; Dallas VA Medical Center, Department of Medicine-Cardiology, University of Texas Southwestern Medical Center, Dallas., Tsai S; Operative Care Line, Dallas VA Medical Center, Division of Vascular Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas., Becker N; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York., Choi JC; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York., Chiu L; Michael E. DeBakey VA Medical Center, VA Health Systems Research and Development Center for Innovations in Quality, Effectiveness and Safety, Department of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas., Scali S; Operative Care Line, Malcolm Randall Veterans Affairs Medical Center, Department of Surgery, University of Florida College of Medicine, Gainesville., Barshes NR; Operative Care Line, Michael E. DeBakey VA Medical Center, Department of Surgery, Baylor College of Medicine, Houston, Texas., Awad S; Operative Care Line, Michael E. DeBakey VA Medical Center, Department of Surgery, Baylor College of Medicine, Houston, Texas., Moursi M; Operative Care Line, Little Rock VA Medical Center, Department of Surgery, University of Arkansas for Medical Services, Little Rock., Koopmann MC; Operative Care Division, Portland VA Medical Center, Portland, Oregon., Sally M; Trauma/Surgical ICU, Oregon Health Sciences University, Portland, Oregon., Ihnat D; Operative Care Line, Minneapolis VA Medical Center, Department of Surgery, University of Minnesota Medical School, Minneapolis., Ramaswamy A; Operative Care Line, Minneapolis VA Medical Center, Department of Surgery, University of Minnesota Medical School, Minneapolis., Gasper W; Operative Care Line, San Francisco VA Health System, Department of Surgery, University of California, San Francisco., Tzeng E; Operative Care Line, Pittsburgh VA Medical Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania., Wilson MA; Operative Care Line, Pittsburgh VA Medical Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania., Tang G; Operative Care Line, Seattle VA Medical Center, Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle., Huang G; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland., Biswas K; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland.
Corporate Authors: TOP Trial Investigators
Source: JAMA [JAMA] 2025 Dec 23; Vol. 334 (24), pp. 2197-2207.
Publication Type: Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial.
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DeBakey VA Medical Center, Department of Medicine-Cardiology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Gregg+LP%22">Gregg LP</searchLink>; Michael E. DeBakey VA Medical Center, VA Health Systems Research and Development Center for Innovations in Quality, Effectiveness and Safety, Department of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Abdullah+SM%22">Abdullah SM</searchLink>; Dallas VA Medical Center, Department of Medicine-Cardiology, University of Texas Southwestern Medical Center, Dallas.<br /><searchLink fieldCode="AU" term="%22Tsai+S%22">Tsai S</searchLink>; Operative Care Line, Dallas VA Medical Center, Division of Vascular Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas.<br /><searchLink fieldCode="AU" term="%22Becker+N%22">Becker N</searchLink>; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York.<br /><searchLink fieldCode="AU" term="%22Choi+JC%22">Choi JC</searchLink>; Operative Care Line, VA New York Harbor Healthcare System, Department of Surgery, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, New York.<br /><searchLink fieldCode="AU" term="%22Chiu+L%22">Chiu L</searchLink>; Michael E. DeBakey VA Medical Center, VA Health Systems Research and Development Center for Innovations in Quality, Effectiveness and Safety, Department of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Scali+S%22">Scali S</searchLink>; Operative Care Line, Malcolm Randall Veterans Affairs Medical Center, Department of Surgery, University of Florida College of Medicine, Gainesville.<br /><searchLink fieldCode="AU" term="%22Barshes+NR%22">Barshes NR</searchLink>; Operative Care Line, Michael E. DeBakey VA Medical Center, Department of Surgery, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Awad+S%22">Awad S</searchLink>; Operative Care Line, Michael E. DeBakey VA Medical Center, Department of Surgery, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Moursi+M%22">Moursi M</searchLink>; Operative Care Line, Little Rock VA Medical Center, Department of Surgery, University of Arkansas for Medical Services, Little Rock.<br /><searchLink fieldCode="AU" term="%22Koopmann+MC%22">Koopmann MC</searchLink>; Operative Care Division, Portland VA Medical Center, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Sally+M%22">Sally M</searchLink>; Trauma/Surgical ICU, Oregon Health Sciences University, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Ihnat+D%22">Ihnat D</searchLink>; Operative Care Line, Minneapolis VA Medical Center, Department of Surgery, University of Minnesota Medical School, Minneapolis.<br /><searchLink fieldCode="AU" term="%22Ramaswamy+A%22">Ramaswamy A</searchLink>; Operative Care Line, Minneapolis VA Medical Center, Department of Surgery, University of Minnesota Medical School, Minneapolis.<br /><searchLink fieldCode="AU" term="%22Gasper+W%22">Gasper W</searchLink>; Operative Care Line, San Francisco VA Health System, Department of Surgery, University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Tzeng+E%22">Tzeng E</searchLink>; Operative Care Line, Pittsburgh VA Medical Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wilson+MA%22">Wilson MA</searchLink>; Operative Care Line, Pittsburgh VA Medical Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Tang+G%22">Tang G</searchLink>; Operative Care Line, Seattle VA Medical Center, Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle.<br /><searchLink fieldCode="AU" term="%22Huang+G%22">Huang G</searchLink>; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland.<br /><searchLink fieldCode="AU" term="%22Biswas+K%22">Biswas K</searchLink>; VA Cooperative Studies Program Coordinating Center, Perry Point, Maryland.
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