Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development.

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Title: Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development.
Authors: Marina-Zárate E; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Sutton HJ; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Lopez PG; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Altheide TK; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Bick M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Burton I; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Ben-Akiva E; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Kaczmarek Michaels K; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Hyacinth K; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA., Healy BS; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA., Lim D; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA., Hangartner L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; IAVI Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Carnathan DG; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA., Silvestri G; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Emory National Primate Research Center and Emory Vaccine Center, Atlanta, GA, USA., Schief WR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA., Irvine DJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, San Diego, CA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Crotty S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA; Consortium for HIV Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, San Diego, CA, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, San Diego, CA, USA. Electronic address: shane@lji.org.
Source: Immunity [Immunity] 2025 Dec 09; Vol. 58 (12), pp. 3094-3112.e7. Date of Electronic Publication: 2025 Nov 07.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2025.10.008