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Imaging and plasma biomarkers for pathological accumulation in Down syndrome.

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Title: Imaging and plasma biomarkers for pathological accumulation in Down syndrome.
Authors: Wisch JK; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA., Jiao Z; Department of Mathematics, Washington University in St. Louis, St. Louis, MO 63130, USA., Kennedy JT; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA., Cohen AD; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Schlachetzki Z; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA., Petersen M; Department of Pharmacology and Neuroscience, Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA., Handen BL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Christian BT; Department of Medical Physics and Psychiatry, University of Wisconsin Madison, Madison, WI 53705-2275, USA., Mapstone M; Department of Neurology, University of California Irvine School of Medicine, Orange, CA 92868-4280, USA., Rosas HD; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA., Lai F; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA., Lee JH; G. H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10033, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10033, USA.; Department of Epidemiology, Columbia University Irving Medical Center, New York, NY 10032, USA., Krinsky-McHale SJ; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA., Schmitt FA; Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA., Harp JP; Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA., Hom C; Department of Psychiatry, University of California Irvine School of Medicine, Orange, CA 92868-4280, USA., Lott IT; Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA 92868-4280, USA., Hartley S; Waisman Center, University of Wisconsin, Madison, WI 53705, USA., Zaman S; Cambridge Intellectual and Developmental Disabilities Research Group, University of Cambridge, Cambridge, CB2 8AH, UK., Ptomey L; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA., Burns JM; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA., Tudorascu D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA., Ibanez L; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA., Rafii MS; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA., Head E; Department of Pathology, Gillespie Neuroscience Research Facility, University of California-Irvine, Irvine, CA 92617, USA., Ances BM; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Source: Brain : a journal of neurology [Brain] 2026 Jun 03; Vol. 149 (6), pp. 1944-1957.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wisch+JK%22">Wisch JK</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+Z%22">Jiao Z</searchLink>; Department of Mathematics, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+JT%22">Kennedy JT</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+AD%22">Cohen AD</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Schlachetzki+Z%22">Schlachetzki Z</searchLink>; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+M%22">Petersen M</searchLink>; Department of Pharmacology and Neuroscience, Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.<br /><searchLink fieldCode="AU" term="%22Handen+BL%22">Handen BL</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Christian+BT%22">Christian BT</searchLink>; Department of Medical Physics and Psychiatry, University of Wisconsin Madison, Madison, WI 53705-2275, USA.<br /><searchLink fieldCode="AU" term="%22Mapstone+M%22">Mapstone M</searchLink>; Department of Neurology, University of California Irvine School of Medicine, Orange, CA 92868-4280, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+HD%22">Rosas HD</searchLink>; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; G. 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Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10033, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10033, USA.; Department of Epidemiology, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Krinsky-McHale+SJ%22">Krinsky-McHale SJ</searchLink>; Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.<br /><searchLink fieldCode="AU" term="%22Schmitt+FA%22">Schmitt FA</searchLink>; Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Harp+JP%22">Harp JP</searchLink>; Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Hom+C%22">Hom C</searchLink>; Department of Psychiatry, University of California Irvine School of Medicine, Orange, CA 92868-4280, USA.<br /><searchLink fieldCode="AU" term="%22Lott+IT%22">Lott IT</searchLink>; Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA 92868-4280, USA.<br /><searchLink fieldCode="AU" term="%22Hartley+S%22">Hartley S</searchLink>; Waisman Center, University of Wisconsin, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+S%22">Zaman S</searchLink>; Cambridge Intellectual and Developmental Disabilities Research Group, University of Cambridge, Cambridge, CB2 8AH, UK.<br /><searchLink fieldCode="AU" term="%22Ptomey+L%22">Ptomey L</searchLink>; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.<br /><searchLink fieldCode="AU" term="%22Burns+JM%22">Burns JM</searchLink>; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.<br /><searchLink fieldCode="AU" term="%22Tudorascu+D%22">Tudorascu D</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Ibanez+L%22">Ibanez L</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Rafii+MS%22">Rafii MS</searchLink>; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of USC, Los Angeles, CA 90033, USA.<br /><searchLink fieldCode="AU" term="%22Head+E%22">Head E</searchLink>; Department of Pathology, Gillespie Neuroscience Research Facility, University of California-Irvine, Irvine, CA 92617, USA.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
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              Text: 2026 Jun 03
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