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Safety and efficacy of REP 2139-Mg in patients with HDV-related advanced liver disease in an international compassionate access program.

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Title: Safety and efficacy of REP 2139-Mg in patients with HDV-related advanced liver disease in an international compassionate access program.
Authors: Stern C; Department of Hepatology and Gastroenterology, Centre Hospitalier de Versailles, Le Chesnay, France. Electronic address: cstern@ght78sud.fr., Loustaud-Ratti V; Hepato-gastroenterology department, University Hospital Center and INSERM U1248, Limoges University, Limoges, France., Yurdaydin C; Koç University Medical School, Department of Gastroenterology and Hepatology, Istanbul, Turkey., Brancaccio G; Infectious Diseases, Department of Life Sciences, Health and Health Professions Link Campus University Rome, Rome, Italy., Jachs M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Reiberger T; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Bardou-Jacquet E; Service des Maladies du Foie, CHU de Rennes, Rennes, France., Metivier S; Service d'hépatologie, CHU Rangueil, Toulouse, France., Alric L; Internal Medicine - Digestive department - CHU Rangueil, Toulouse III University, Toulouse, France., Colombain L; Centre Hospitalier de Perpignan, Perpignan, France., Meszaros M; Hepatogastroenterology and Liver Transplantation Department, CHU Montpellier, Montpellier, France., Mathurin P; Service Hepatologie et Gastroenterologie, CHU Lille, Lillie, France., Yardeni D; Soroka Medical Center, Be'er Sheva, Israel., Etzion O; Soroka Medical Center, Be'er Sheva, Israel., Neumann-Haefelin C; Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Gastroenterology and Hepatology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany., Douglas M; The University of Sydney at Westmead Hospital and Westmead Institute for Medical Research, Westmead, Australia., Poulin S; Clinique L' Agora, Montreal, Canada., Bazinet M; Replicor Inc. Montreal, Canada., Metin RO; Prof. Cemil Taşçıoğlu City Hospital, Department of Gastroenterology, Istanbul, Turkey., Vitale A; Chirurgia Generale, Università di Padova, Padua, Italy., Gaeta GB; Infectious Diseases, Campania University Luigi Vanvitelli, Naples, Italy., Schwarz M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Ben-Ali S; Service Hépato-Gastroentérologie, Hôpital Saint-Joseph, INSERM, UMR 1252 IRD SESSTIM, Aix Marseille Université, Marseille, France., Bedoya JU; Hepatogastroenterology and Liver Transplantation Department, CHU Montpellier, Montpellier, France., Testoni B; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France., Zoulim F; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France., Plissonnier ML; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France., Levrero M; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France., Paradis V; Pathology department, Hôpital Beaujon, Clichy, France., Francois S; Hepato-gastroenterology department, University Hospital Center and INSERM U1248, Limoges University, Limoges, France., de Freitas C; Hepatology department, Hôpital Beaujon, Clichy, France., Kaysin F; Koç University Medical School, Department of Gastroenterology and Hepatology, Istanbul, Turkey., Lecomte L; Service Hépato-Gastroentérologie, Hôpital Saint-Joseph, INSERM, UMR 1252 IRD SESSTIM, Aix Marseille Université, Marseille, France., Morvan C; Centre Hospitalier de Perpignan, Perpignan, France., Schramko J; The University of Sydney at Westmead Hospital and Westmead Institute for Medical Research, Westmead, Australia., Bondezi K; The University of Sydney at Westmead Hospital and Westmead Institute for Medical Research, Westmead, Australia., Baril MÉ; Clinique L' Agora, Montreal, Canada., Brichler S; Centre national de référence des hépatites B, C et Delta - Laboratoire associé, Hôpital Avicenne, Bobigny, France., Gerber A; Centre national de référence des hépatites B, C et Delta - Laboratoire associé, Hôpital Avicenne, Bobigny, France., Gordien E; Centre national de référence des hépatites B, C et Delta - Laboratoire associé, Hôpital Avicenne, Bobigny, France., Mackiewicz V; Service de Virologie, Hôpital Bichat, Paris, France., Dahari H; The Program for Experimental and Theoretical Modeling, Division of Hepatology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States., Svicher V; Dipartimento di Biologia, Università degli Studi di Roma Tor Vergata, Rome, Italy., Chevaliez S; Service de Virologie, Hôpital Henri Mondor, Créteil, France., Vaillant A; Replicor Inc. Montreal, Canada., Bourliere M; Service Hépato-Gastroentérologie, Hôpital Saint-Joseph, INSERM, UMR 1252 IRD SESSTIM, Aix Marseille Université, Marseille, France. Electronic address: mbourliere@hopital-saint-joseph.fr.
Source: Journal of hepatology [J Hepatol] 2026 Mar; Vol. 84 (3), pp. 531-542. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficacy of REP 2139-Mg in patients with HDV-related advanced liver disease in an international compassionate access program.
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  Data: <searchLink fieldCode="AU" term="%22Stern+C%22">Stern C</searchLink>; Department of Hepatology and Gastroenterology, Centre Hospitalier de Versailles, Le Chesnay, France. 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Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Metin+RO%22">Metin RO</searchLink>; Prof. Cemil Taşçıoğlu City Hospital, Department of Gastroenterology, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Vitale+A%22">Vitale A</searchLink>; Chirurgia Generale, Università di Padova, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Gaeta+GB%22">Gaeta GB</searchLink>; Infectious Diseases, Campania University Luigi Vanvitelli, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Schwarz+M%22">Schwarz M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Ben-Ali+S%22">Ben-Ali S</searchLink>; Service Hépato-Gastroentérologie, Hôpital Saint-Joseph, INSERM, UMR 1252 IRD SESSTIM, Aix Marseille Université, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bedoya+JU%22">Bedoya JU</searchLink>; Hepatogastroenterology and Liver Transplantation Department, CHU Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Testoni+B%22">Testoni B</searchLink>; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France.<br /><searchLink fieldCode="AU" term="%22Zoulim+F%22">Zoulim F</searchLink>; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France.<br /><searchLink fieldCode="AU" term="%22Plissonnier+ML%22">Plissonnier ML</searchLink>; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France.<br /><searchLink fieldCode="AU" term="%22Levrero+M%22">Levrero M</searchLink>; Lyon Hepatology Institute, IHU EVEREST; UMR PaThLiv U1350, INSERM, Université Claude Bernard Lyon 1; Hospices Civils de Lyon; Lyon, France.<br /><searchLink fieldCode="AU" term="%22Paradis+V%22">Paradis V</searchLink>; Pathology department, Hôpital Beaujon, Clichy, France.<br /><searchLink fieldCode="AU" term="%22Francois+S%22">Francois S</searchLink>; Hepato-gastroenterology department, University Hospital Center and INSERM U1248, Limoges University, Limoges, France.<br /><searchLink fieldCode="AU" term="%22de+Freitas+C%22">de Freitas C</searchLink>; Hepatology department, Hôpital Beaujon, Clichy, France.<br /><searchLink fieldCode="AU" term="%22Kaysin+F%22">Kaysin F</searchLink>; Koç University Medical School, Department of Gastroenterology and Hepatology, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Lecomte+L%22">Lecomte L</searchLink>; Service Hépato-Gastroentérologie, Hôpital Saint-Joseph, INSERM, UMR 1252 IRD SESSTIM, Aix Marseille Université, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Morvan+C%22">Morvan C</searchLink>; Centre Hospitalier de Perpignan, Perpignan, France.<br /><searchLink fieldCode="AU" term="%22Schramko+J%22">Schramko J</searchLink>; The University of Sydney at Westmead Hospital and Westmead Institute for Medical Research, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Bondezi+K%22">Bondezi K</searchLink>; The University of Sydney at Westmead Hospital and Westmead Institute for Medical Research, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Baril+MÉ%22">Baril MÉ</searchLink>; Clinique L' Agora, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Brichler+S%22">Brichler S</searchLink>; Centre national de référence des hépatites B, C et Delta - Laboratoire associé, Hôpital Avicenne, Bobigny, France.<br /><searchLink fieldCode="AU" term="%22Gerber+A%22">Gerber A</searchLink>; Centre national de référence des hépatites B, C et Delta - Laboratoire associé, Hôpital Avicenne, Bobigny, France.<br /><searchLink fieldCode="AU" term="%22Gordien+E%22">Gordien E</searchLink>; Centre national de référence des hépatites B, C et Delta - Laboratoire associé, Hôpital Avicenne, Bobigny, France.<br /><searchLink fieldCode="AU" term="%22Mackiewicz+V%22">Mackiewicz V</searchLink>; Service de Virologie, Hôpital Bichat, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dahari+H%22">Dahari H</searchLink>; The Program for Experimental and Theoretical Modeling, Division of Hepatology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States.<br /><searchLink fieldCode="AU" term="%22Svicher+V%22">Svicher V</searchLink>; Dipartimento di Biologia, Università degli Studi di Roma Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Chevaliez+S%22">Chevaliez S</searchLink>; Service de Virologie, Hôpital Henri Mondor, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Vaillant+A%22">Vaillant A</searchLink>; Replicor Inc. 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