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Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi.

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Title: Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi.
Authors: Ndeketa L; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi; University of Liverpool, Liverpool, UK; Kamuzu University of Health Sciences, Blantyre, Malawi., Haine V; GSK, Wavre, Belgium. Electronic address: valerie.x.haine@gsk.com., Debois M; GSK, Wavre, Belgium., Asante KP; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana; London School of Hygiene & Tropical Medicine, London, UK., Agyapong PD; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Kaali S; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Devadiga R; GSK, Bangalore, India., Harrison SBE; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Boahen O; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., French N; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi; University of Liverpool, Liverpool, UK., Kayan K; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Ogutu B; Centre for Research in Therapeutic Sciences, Strathmore University, Nairobi, Kenya; Kenya Medical Research Institute, Centre for Clinical Research, Nairobi, Kenya., Adeniji E; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Kariuki S; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Owusu-Agyei S; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Olewe F; Centre for Research in Therapeutic Sciences, Strathmore University, Nairobi, Kenya., Jere TM; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Maleta K; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Mategula D; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi; Kamuzu University of Health Sciences, Blantyre, Malawi., Mzanga P; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Phiri VK; Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi., Ansah PO; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Orimbo J; Centre for Research in Therapeutic Sciences, Strathmore University, Nairobi, Kenya; Kenya Medical Research Institute, Centre for Clinical Research, Nairobi, Kenya., Ansah NA; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Orsini M; 4 Clinics, Waterloo, Belgium., Ong'echa JM; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Oduro AR; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Sifuna PM; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Azongo DK; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Otieno W; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Bangre O; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Kaburise MB; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Ababio LO; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Oyieko JN; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Sing'oei V; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Amoit SK; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Nyangulu W; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Schuerman L; GSK, Wavre, Belgium., Awuni D; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Navrongo, Ghana., Ochieng BO; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Onyango I; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Odera-Ojwang P; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Oguk EA; Kenya Medical Research Institute-Walter Reed Project, US Army Medical Research Directorate-Kenya, Kombewa, Kenya., Mendoza YG; GSK, Wavre, Belgium., Cherop RY; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Okoth GO; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Cravcenco C; GSK, Wavre, Belgium., Chipatala R; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Roman F; GSK, Wavre, Belgium., Oneko M; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Savic M; GSK, Wavre, Belgium.
Corporate Authors: RTS,S Epidemiology EPI-MAL-003 Study Group
Source: The Lancet. Global health [Lancet Glob Health] 2026 Jan; Vol. 14 (1), pp. e61-e69. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Clinical Trial, Phase IV; Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE
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