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No association of Alzheimer disease with the joint effect of HFE and TF in the mid-western Amish.

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Title: No association of Alzheimer disease with the joint effect of HFE and TF in the mid-western Amish.
Authors: Liu Y; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA jlh213@case.edu yxl3272@case.edu., Song YE; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Lynn A; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Wang W; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Miskimen K; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Fuzzell SL; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Hochstetler SD; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Laux RA; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Caywood LJ; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Clouse JE; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Herington SD; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Wang P; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Gulyayev AV; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Dorfsman DA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Moore NC; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Main LR; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Prough MB; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Zaman AF; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Adams LD; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Ogrocki P; Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Lerner AJ; Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Vance J; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Scott WK; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Haines JL; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA jlh213@case.edu yxl3272@case.edu.; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Source: Journal of medical genetics [J Med Genet] 2026 Jan 20; Vol. 63 (2), pp. 93-94. Date of Electronic Publication: 2026 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Association Country of Publication: England NLM ID: 2985087R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-6244 (Electronic) Linking ISSN: 00222593 NLM ISO Abbreviation: J Med Genet Subsets: MEDLINE; In Process
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA jlh213@case.edu yxl3272@case.edu.<br /><searchLink fieldCode="AU" term="%22Song+YE%22">Song YE</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Lynn+A%22">Lynn A</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Miskimen+K%22">Miskimen K</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Fuzzell+SL%22">Fuzzell SL</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Hochstetler+SD%22">Hochstetler SD</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Laux+RA%22">Laux RA</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Caywood+LJ%22">Caywood LJ</searchLink>; John P. 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Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Moore+NC%22">Moore NC</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Main+LR%22">Main LR</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Prough+MB%22">Prough MB</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Zaman+AF%22">Zaman AF</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Adams+LD%22">Adams LD</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Whitehead+P%22">Whitehead P</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Ogrocki+P%22">Ogrocki P</searchLink>; Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Lerner+AJ%22">Lerner AJ</searchLink>; Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Vance+J%22">Vance J</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Cuccaro+ML%22">Cuccaro ML</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Scott+WK%22">Scott WK</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Pericak-Vance+MA%22">Pericak-Vance MA</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Haines+JL%22">Haines JL</searchLink>; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA jlh213@case.edu yxl3272@case.edu.; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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