Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B.
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| Title: | Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B. |
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| Authors: | Godrich D; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Pasteris J; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Martin ER; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Kunkle B; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, Philadelphia, Pennsylvania, USA., Hamilton K; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Wang H; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Lee WP; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Dumitrescu L; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Hohman TJ; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Mayeux R; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA., Crane PK; Department of Medicine, University of Washington, Seattle, Washington, USA., Keene CD; Department of Pathology, University of Washington, Seattle, Washington, USA., Latimer C; Department of Pathology, University of Washington, Seattle, Washington, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, Washington, USA., Kofler J; Department of Pathology, University of Washington, Seattle, Washington, USA., Kamboh MI; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Molina-Porcel L; Neurology Service, Hospital Clínic, Fundació Recerca Clínic Barcelona (FRCB). Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, Sarrià-Sant Gervasi, Barcelona, Spain., Schellenberg G; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Pericak-Vance MA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Cuccaro M; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Scott WK; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA., Rundek T; Department of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA., Kukull W; Department of Medicine, University of Washington, Seattle, Washington, USA., Montine T; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Beecham GW; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA. |
| Corporate Authors: | Alzheimer's Disease Genetics Consortium (ADGC) |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Nov; Vol. 21 (11), pp. e70760. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.70760 |
