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Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.

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Title: Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.
Authors: Rebhun RB; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Cruz SM; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States., York D; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Mazcko CN; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States., Razmara AM; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States., Patkar S; Artificial Intelligence Resource, Molecular Imaging Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States., Judge SJ; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States., Sholevar CJ; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States., Shah RK; Departments of Medicine (Hematology and Oncology) and Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States., Zamora AE; Departments of Medicine (Hematology and Oncology) and Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States., Al-Nadaf S; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Vail DM; Department of Medical Sciences, School of Veterinary Medicine, and The Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, United States., Fan TM; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, and Cancer Center at Illinois, University of Illinois, Urbana, IL, United States., Burton JH; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine, Fort Collins, CO, United States., Luker ME; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Skorupski KA; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Lejeune AT; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Woolard K; Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States., Stewart SL; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, Davis, CA, United States., Sparger EE; Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States., Young J; Veterinary Center for Clinical Trials, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States., Cohen-Davidyan T; Veterinary Center for Clinical Trials, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States., Huang E; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, MD, United States., Beck JA; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States., Murphy WJ; Department of Dermatology, University of California, Davis/Sacramento, Davis, CA, United States., Kent MS; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., Culp WTN; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States., LeBlanc AK; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States., Canter RJ; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States.
Source: Frontiers in immunology [Front Immunol] 2025 Oct 23; Vol. 16, pp. 1672790. Date of Electronic Publication: 2025 Oct 23 (Print Publication: 2025).
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Rebhun+RB%22">Rebhun RB</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Cruz+SM%22">Cruz SM</searchLink>; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States.<br /><searchLink fieldCode="AU" term="%22York+D%22">York D</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Mazcko+CN%22">Mazcko CN</searchLink>; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Razmara+AM%22">Razmara AM</searchLink>; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States.<br /><searchLink fieldCode="AU" term="%22Patkar+S%22">Patkar S</searchLink>; Artificial Intelligence Resource, Molecular Imaging Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Judge+SJ%22">Judge SJ</searchLink>; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States.<br /><searchLink fieldCode="AU" term="%22Sholevar+CJ%22">Sholevar CJ</searchLink>; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States.<br /><searchLink fieldCode="AU" term="%22Shah+RK%22">Shah RK</searchLink>; Departments of Medicine (Hematology and Oncology) and Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Zamora+AE%22">Zamora AE</searchLink>; Departments of Medicine (Hematology and Oncology) and Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.<br /><searchLink fieldCode="AU" term="%22Al-Nadaf+S%22">Al-Nadaf S</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Vail+DM%22">Vail DM</searchLink>; Department of Medical Sciences, School of Veterinary Medicine, and The Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, United States.<br /><searchLink fieldCode="AU" term="%22Fan+TM%22">Fan TM</searchLink>; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, and Cancer Center at Illinois, University of Illinois, Urbana, IL, United States.<br /><searchLink fieldCode="AU" term="%22Burton+JH%22">Burton JH</searchLink>; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine, Fort Collins, CO, United States.<br /><searchLink fieldCode="AU" term="%22Luker+ME%22">Luker ME</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Skorupski+KA%22">Skorupski KA</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Lejeune+AT%22">Lejeune AT</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Woolard+K%22">Woolard K</searchLink>; Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Stewart+SL%22">Stewart SL</searchLink>; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Sparger+EE%22">Sparger EE</searchLink>; Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Young+J%22">Young J</searchLink>; Veterinary Center for Clinical Trials, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Cohen-Davidyan+T%22">Cohen-Davidyan T</searchLink>; Veterinary Center for Clinical Trials, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Huang+E%22">Huang E</searchLink>; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.<br /><searchLink fieldCode="AU" term="%22Beck+JA%22">Beck JA</searchLink>; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Murphy+WJ%22">Murphy WJ</searchLink>; Department of Dermatology, University of California, Davis/Sacramento, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Kent+MS%22">Kent MS</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22Culp+WTN%22">Culp WTN</searchLink>; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, United States.<br /><searchLink fieldCode="AU" term="%22LeBlanc+AK%22">LeBlanc AK</searchLink>; Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Canter+RJ%22">Canter RJ</searchLink>; Division of Surgical Oncology, Department of Surgery, University of California, Davis/Sacramento, CA, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 Oct 23; Vol. 16, pp. 1672790. <i>Date of Electronic Publication: </i>2025 Oct 23 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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