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A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.

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Title: A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.
Authors: Tung SY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lee KF; Department of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan., Hsieh YY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Cheng KC; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan., Lee KC; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.; College of Medicine, Chang Gung University, Kaohsiung, Taiwan., Lee LY; Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan., Chen WP; Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan., Chen CC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan., Teng CC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan., Hsieh MC; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan., Huang CY; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan., Kuo HC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2025 Oct 10; Vol. 22 (16), pp. 4278-4294. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.
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  Data: <searchLink fieldCode="AU" term="%22Tung+SY%22">Tung SY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KF%22">Lee KF</searchLink>; Department of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YY%22">Hsieh YY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+KC%22">Cheng KC</searchLink>; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KC%22">Lee KC</searchLink>; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.; College of Medicine, Chang Gung University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+LY%22">Lee LY</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WP%22">Chen WP</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Teng+CC%22">Teng CC</searchLink>; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+MC%22">Hsieh MC</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CY%22">Huang CY</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+HC%22">Kuo HC</searchLink>; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan.
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