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Molecular mechanisms and biomarkers of total parenteral nutrition-induced hepatotoxicity revealed by iTRAQ proteomics analysis.

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Title: Molecular mechanisms and biomarkers of total parenteral nutrition-induced hepatotoxicity revealed by iTRAQ proteomics analysis.
Authors: Hsieh YY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan., Tsai JJ; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Taipei Veterans General Hospital, Yuan-Shan/Su-Ao Branch, Taipei City, Taiwan.; Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, New Taipei City, Taiwan., Tung SY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan., Lee KC; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.; College of Medicine, Chang Gung University, Kaohsiung, Taiwan., Cheng KC; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan., Lee KF; Department of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan., Hsieh MC; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan., Huang CY; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan., Teng CC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan., Shen CH; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan., Kuo HC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2025 Oct 10; Vol. 22 (16), pp. 4295-4312. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hsieh+YY%22">Hsieh YY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+JJ%22">Tsai JJ</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Taipei Veterans General Hospital, Yuan-Shan/Su-Ao Branch, Taipei City, Taiwan.; Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+SY%22">Tung SY</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KC%22">Lee KC</searchLink>; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.; College of Medicine, Chang Gung University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+KC%22">Cheng KC</searchLink>; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KF%22">Lee KF</searchLink>; Department of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+MC%22">Hsieh MC</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CY%22">Huang CY</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Teng+CC%22">Teng CC</searchLink>; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shen+CH%22">Shen CH</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+HC%22">Kuo HC</searchLink>; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2025 Oct 10; Vol. 22 (16), pp. 4295-4312. <i>Date of Electronic Publication: </i>2025 Oct 10 (<i>Print Publication: </i>2025).
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