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Pt(IV) Prodrugs Bearing Sunitinib-Derived Ligands Display Exceptional Anticancer Activity against Renal Cell Carcinoma When Compared to Conventional Platinum Chemotherapy.

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Title: Pt(IV) Prodrugs Bearing Sunitinib-Derived Ligands Display Exceptional Anticancer Activity against Renal Cell Carcinoma When Compared to Conventional Platinum Chemotherapy.
Authors: Beirne DF; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland., Arakelyan J; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China., Forner M; Universita' di Padova, Dipartimento di Scienze Del Farmaco, Padova 35131, Italy., Choe HJ; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China., Kriukov K; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China., Dempsey E; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.; Kathleen Londsdale Institute for Human Health Research, Maynooth University, Maynooth W23 F2h6 Ireland., Gandin V; Universita' di Padova, Dipartimento di Scienze Del Farmaco, Padova 35131, Italy., Velasco-Torrijos T; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.; Kathleen Londsdale Institute for Human Health Research, Maynooth University, Maynooth W23 F2h6 Ireland., Babak MV; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China., Montagner D; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.; Kathleen Londsdale Institute for Human Health Research, Maynooth University, Maynooth W23 F2h6 Ireland.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24294-24304. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pt(IV) Prodrugs Bearing Sunitinib-Derived Ligands Display Exceptional Anticancer Activity against Renal Cell Carcinoma When Compared to Conventional Platinum Chemotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Beirne+DF%22">Beirne DF</searchLink>; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.<br /><searchLink fieldCode="AU" term="%22Arakelyan+J%22">Arakelyan J</searchLink>; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Forner+M%22">Forner M</searchLink>; Universita' di Padova, Dipartimento di Scienze Del Farmaco, Padova 35131, Italy.<br /><searchLink fieldCode="AU" term="%22Choe+HJ%22">Choe HJ</searchLink>; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Kriukov+K%22">Kriukov K</searchLink>; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Dempsey+E%22">Dempsey E</searchLink>; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.; Kathleen Londsdale Institute for Human Health Research, Maynooth University, Maynooth W23 F2h6 Ireland.<br /><searchLink fieldCode="AU" term="%22Gandin+V%22">Gandin V</searchLink>; Universita' di Padova, Dipartimento di Scienze Del Farmaco, Padova 35131, Italy.<br /><searchLink fieldCode="AU" term="%22Velasco-Torrijos+T%22">Velasco-Torrijos T</searchLink>; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.; Kathleen Londsdale Institute for Human Health Research, Maynooth University, Maynooth W23 F2h6 Ireland.<br /><searchLink fieldCode="AU" term="%22Babak+MV%22">Babak MV</searchLink>; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Montagner+D%22">Montagner D</searchLink>; Department of Chemistry, Maynooth University, Maynooth W23 F2h6, Ireland.; Kathleen Londsdale Institute for Human Health Research, Maynooth University, Maynooth W23 F2h6 Ireland.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24294-24304. <i>Date of Electronic Publication: </i>2025 Nov 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.5c02196
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              Text: 2025 Nov 27
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