Development of a targeted BioPROTAC degrader selective for misfolded SOD1.
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| Title: | Development of a targeted BioPROTAC degrader selective for misfolded SOD1. |
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| Authors: | Chisholm CG; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia. christen@uow.edu.au., Bartlett R; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Brown ML; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Proctor EJ; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Farrawell NE; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Gorman J; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Delerue F; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Department of Genetics, The University of Texas MD Anderson Cancer Centre, Houston, TX, USA., Ittner LM; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Celosia Therapeutics, Sydney, NSW, Australia., Vine-Perrow KL; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Ecroyd H; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Cashman NR; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; ProMIS Neurosciences, Toronto, ON, Canada., Saunders DN; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., McAlary L; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Lum JS; Molecular Horizons and School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW, Australia. jlum@uow.edu.au., Yerbury JJ; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia. |
| Source: | Nature communications [Nat Commun] 2025 Nov 10; Vol. 16 (1), pp. 9713. Date of Electronic Publication: 2025 Nov 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65481-w |
