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Development of a targeted BioPROTAC degrader selective for misfolded SOD1.

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Title: Development of a targeted BioPROTAC degrader selective for misfolded SOD1.
Authors: Chisholm CG; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia. christen@uow.edu.au., Bartlett R; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Brown ML; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Proctor EJ; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Farrawell NE; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Gorman J; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Delerue F; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Department of Genetics, The University of Texas MD Anderson Cancer Centre, Houston, TX, USA., Ittner LM; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Celosia Therapeutics, Sydney, NSW, Australia., Vine-Perrow KL; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Ecroyd H; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Cashman NR; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; ProMIS Neurosciences, Toronto, ON, Canada., Saunders DN; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., McAlary L; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia., Lum JS; Molecular Horizons and School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW, Australia. jlum@uow.edu.au., Yerbury JJ; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.
Source: Nature communications [Nat Commun] 2025 Nov 10; Vol. 16 (1), pp. 9713. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of a targeted BioPROTAC degrader selective for misfolded SOD1.
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  Data: <searchLink fieldCode="AU" term="%22Chisholm+CG%22">Chisholm CG</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia. christen@uow.edu.au.<br /><searchLink fieldCode="AU" term="%22Bartlett+R%22">Bartlett R</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Brown+ML%22">Brown ML</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Proctor+EJ%22">Proctor EJ</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Farrawell+NE%22">Farrawell NE</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gorman+J%22">Gorman J</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Delerue+F%22">Delerue F</searchLink>; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Department of Genetics, The University of Texas MD Anderson Cancer Centre, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ittner+LM%22">Ittner LM</searchLink>; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Celosia Therapeutics, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Vine-Perrow+KL%22">Vine-Perrow KL</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ecroyd+H%22">Ecroyd H</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cashman+NR%22">Cashman NR</searchLink>; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; ProMIS Neurosciences, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Saunders+DN%22">Saunders DN</searchLink>; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22McAlary+L%22">McAlary L</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lum+JS%22">Lum JS</searchLink>; Molecular Horizons and School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW, Australia. jlum@uow.edu.au.<br /><searchLink fieldCode="AU" term="%22Yerbury+JJ%22">Yerbury JJ</searchLink>; Molecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.
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              Text: 2025 Nov 10
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