A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins.
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| Title: | A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins. |
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| Authors: | He S; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Meister D; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Khan S; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Mohammadzadeh A; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Delgadillo Silva L; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Rutter GA; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Diabetes, Endocrinology and Medicine, Faculty of Medicine, Imperial College, London, UK.; LKC School of Medicine, Nanyang Technological College, Singapore, Republic of Singapore.; Research Institute of the McGill University Health Centre, Montreal, Canada., Trant JF; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.; WE-Spark Health Institute, Windsor, ON, Canada.; Binary Star Research Services, LaSalle, ON, Canada.; Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada., Lim GE; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. gareth.lim@umontreal.ca.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. gareth.lim@umontreal.ca. |
| Source: | Cell death & disease [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 825. Date of Electronic Publication: 2025 Nov 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-025-08150-6 |
