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Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline.

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Title: Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline.
Authors: Portugal CC; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal., Almeida TO; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; ICBAS - School of Medicine and Biomedical Sciences, Porto, Portugal., Tedim-Moreira J; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; FMUP - Departamento de Biomedicina, Faculdade de Medicina da Universidade Do Porto, Porto, Portugal., Silva C; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal., Canedo T; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; School of Medicine, ICVS - Life and Health Sciences Research Institute, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Galvão J; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal., Magalhães A; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal., Summavielle T; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal., Bai X; Department of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.; Center for Gender-Specific Biology and Medicine (CGBM), Saarland University, Homburg, 66421, Germany., Kirchhoff F; Department of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.; Center for Gender-Specific Biology and Medicine (CGBM), Saarland University, Homburg, 66421, Germany., Rubinstein B; Stowers Institute for Medical Research, Kansas City, MO, USA., Moreira I; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal., Costa J; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Guedes J; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Pinto IM; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; FMUP - Departamento de Biomedicina, Faculdade de Medicina da Universidade Do Porto, Porto, Portugal.; INL - International Iberian Nanotechnology Laboratory, Braga, Portugal., Peça J; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal., Socodato R; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal. renato.socodato@ibmc.up.pt.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. renato.socodato@ibmc.up.pt., Relvas JB; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal. jrelvas@ibmc.up.pt.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. jrelvas@ibmc.up.pt.; FMUP - Departamento de Biomedicina, Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. jrelvas@ibmc.up.pt.
Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Nov 10; Vol. 22 (1), pp. 264. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline.
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  Data: <searchLink fieldCode="AU" term="%22Portugal+CC%22">Portugal CC</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Almeida+TO%22">Almeida TO</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; ICBAS - School of Medicine and Biomedical Sciences, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Tedim-Moreira+J%22">Tedim-Moreira J</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; FMUP - Departamento de Biomedicina, Faculdade de Medicina da Universidade Do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Silva+C%22">Silva C</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Canedo+T%22">Canedo T</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; School of Medicine, ICVS - Life and Health Sciences Research Institute, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.<br /><searchLink fieldCode="AU" term="%22Galvão+J%22">Galvão J</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Magalhães+A%22">Magalhães A</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Summavielle+T%22">Summavielle T</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Bai+X%22">Bai X</searchLink>; Department of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.; Center for Gender-Specific Biology and Medicine (CGBM), Saarland University, Homburg, 66421, Germany.<br /><searchLink fieldCode="AU" term="%22Kirchhoff+F%22">Kirchhoff F</searchLink>; Department of Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.; Center for Gender-Specific Biology and Medicine (CGBM), Saarland University, Homburg, 66421, Germany.<br /><searchLink fieldCode="AU" term="%22Rubinstein+B%22">Rubinstein B</searchLink>; Stowers Institute for Medical Research, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Moreira+I%22">Moreira I</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Costa+J%22">Costa J</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Guedes+J%22">Guedes J</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Pinto+IM%22">Pinto IM</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal.; FMUP - Departamento de Biomedicina, Faculdade de Medicina da Universidade Do Porto, Porto, Portugal.; INL - International Iberian Nanotechnology Laboratory, Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Peça+J%22">Peça J</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Socodato+R%22">Socodato R</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal. renato.socodato@ibmc.up.pt.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. renato.socodato@ibmc.up.pt.<br /><searchLink fieldCode="AU" term="%22Relvas+JB%22">Relvas JB</searchLink>; i3S - Instituto de Investigação E Inovação Em Saúde, Universidade Do Porto, Porto, Portugal. jrelvas@ibmc.up.pt.; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. jrelvas@ibmc.up.pt.; FMUP - Departamento de Biomedicina, Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. jrelvas@ibmc.up.pt.
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  Data: <searchLink fieldCode="JN" term="%22101222974%22">Journal of neuroinflammation</searchLink> [J Neuroinflammation] 2025 Nov 10; Vol. 22 (1), pp. 264. <i>Date of Electronic Publication: </i>2025 Nov 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101222974 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1742-2094 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217422094%22">17422094 </searchLink><i>NLM ISO Abbreviation: </i>J Neuroinflammation <i>Subsets: </i>MEDLINE
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