Alirocumab therapy effectively suppresses colorectal cancer cell growth and invasion in nude mouse liver - PCSK9 is a key driver of PI3K/Akt/p-Bad-mediated cell proliferation and antiapoptotic signaling.
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| Title: | Alirocumab therapy effectively suppresses colorectal cancer cell growth and invasion in nude mouse liver - PCSK9 is a key driver of PI3K/Akt/p-Bad-mediated cell proliferation and antiapoptotic signaling. |
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| Authors: | Yeh JN; Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, China., Chen HH; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan., Lan XW; Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, China., Huang CR; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Chen YL; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan., Wang YT; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan., Shao PL; Department of Nursing, Asia University, Taichung, Taiwan., Ko SF; Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan., Guo J; Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, China., Yip HK; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. |
| Source: | International journal of surgery (London, England) [Int J Surg] 2026 Feb 01; Vol. 112 (2), pp. 2771-2790. Date of Electronic Publication: 2025 Nov 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101228232 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-9159 (Electronic) Linking ISSN: 17439159 NLM ISO Abbreviation: Int J Surg Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41217411 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Alirocumab therapy effectively suppresses colorectal cancer cell growth and invasion in nude mouse liver - PCSK9 is a key driver of PI3K/Akt/p-Bad-mediated cell proliferation and antiapoptotic signaling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yeh+JN%22">Yeh JN</searchLink>; Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lan+XW%22">Lan XW</searchLink>; Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+CR%22">Huang CR</searchLink>; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YL%22">Chen YL</searchLink>; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YT%22">Wang YT</searchLink>; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shao+PL%22">Shao PL</searchLink>; Department of Nursing, Asia University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+SF%22">Ko SF</searchLink>; Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Department of Cardiology, The First Affiliated Hospital, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yip+HK%22">Yip HK</searchLink>; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101228232%22">International journal of surgery (London, England)</searchLink> [Int J Surg] 2026 Feb 01; Vol. 112 (2), pp. 2771-2790. <i>Date of Electronic Publication: </i>2025 Nov 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Inc%22">Wolters Kluwer Health, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101228232 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1743-9159 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217439159%22">17439159 </searchLink><i>NLM ISO Abbreviation: </i>Int J Surg <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41217411 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1097/JS9.0000000000003728 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2771 Titles: – TitleFull: Alirocumab therapy effectively suppresses colorectal cancer cell growth and invasion in nude mouse liver - PCSK9 is a key driver of PI3K/Akt/p-Bad-mediated cell proliferation and antiapoptotic signaling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yeh JN – PersonEntity: Name: NameFull: Chen HH – PersonEntity: Name: NameFull: Lan XW – PersonEntity: Name: NameFull: Huang CR – PersonEntity: Name: NameFull: Chen YL – PersonEntity: Name: NameFull: Wang YT – PersonEntity: Name: NameFull: Shao PL – PersonEntity: Name: NameFull: Ko SF – PersonEntity: Name: NameFull: Guo J – PersonEntity: Name: NameFull: Yip HK IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2026 Feb 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1743-9159 Numbering: – Type: volume Value: 112 – Type: issue Value: 2 Titles: – TitleFull: International journal of surgery (London, England) Type: main |
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