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Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis.

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Title: Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis.
Authors: Wang X; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Cramer Z; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Leu NA; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Monaghan K; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Durning K; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Adams-Tzivelekidis S; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Rhoades JH; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Heintz J; Biostatistics Analysis Center, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Tian Y; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Rico J; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Mendez D; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Petroni R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., King AC; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Kim MS; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Matsuda R; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Hanselman O; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Shin AE; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Carrera Rodríguez MF; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Brodsky IE; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Rustgi A; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Li N; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Lengner CJ; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Andrés Blanco M; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 18; Vol. 122 (46), pp. e2510910122. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Cramer+Z%22">Cramer Z</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Leu+NA%22">Leu NA</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Monaghan+K%22">Monaghan K</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Durning+K%22">Durning K</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Adams-Tzivelekidis+S%22">Adams-Tzivelekidis S</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Rhoades+JH%22">Rhoades JH</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Heintz+J%22">Heintz J</searchLink>; Biostatistics Analysis Center, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Rico+J%22">Rico J</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Mendez+D%22">Mendez D</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Petroni+R%22">Petroni R</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22King+AC%22">King AC</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Kim+MS%22">Kim MS</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Matsuda+R%22">Matsuda R</searchLink>; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Hanselman+O%22">Hanselman O</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Shin+AE%22">Shin AE</searchLink>; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.<br /><searchLink fieldCode="AU" term="%22Carrera+Rodríguez+MF%22">Carrera Rodríguez MF</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Brodsky+IE%22">Brodsky IE</searchLink>; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Rustgi+A%22">Rustgi A</searchLink>; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.<br /><searchLink fieldCode="AU" term="%22Li+N%22">Li N</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Lengner+CJ%22">Lengner CJ</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Andrés+Blanco+M%22">Andrés Blanco M</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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