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Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry.

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Title: Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry.
Authors: Chen F; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Sheng X; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wang A; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Xu Y; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hughley R; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Xiong W; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Pooler L; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wan P; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gundell SM; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kigozi G; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Nakigozi G; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Nalugoda F; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Kagaayi J; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Kigozi GN; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Mugamba S; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Kyasanku E; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Nkale J; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Olwa VO; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Lubwama A; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Daama A; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Nakajugo R; Africa Medical and Behavioural Sciences Organization, Wakiso, Uganda., Adusei B; 37 Military Hospital, Accra, Ghana., Jalloh M; Department of Urology, University Cheikh Anta Diop de Dakar, Dakar, Senegal., Gueye SM; Hôpital Général de Grand Yoff, Dakar, Senegal., Adjei AA; Department of Pathology, University of Ghana Medical School College of Health Sciences Korle Bu Accra Ghana, Accra, Ghana., Mensah J; Department of surgery, Division of Urology, Korle-Bu Hospital, Accra, Ghana., Fernandez PW; Division of Urology, Stellenbosch University, Cape Town, South Africa., Adebiyi AO; University College Hospital, Ibadan, Nigeria., Olufemi Ogunbiyi J; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Aisuodionoe-Shadrach OI; College of Health Sciences, University of Abuja & University of Abuja Teaching Hospital, Abuja, Nigeria; Cancer Science Centre, Abuja, Nigeria., Petersen L; Mediclinic Precise, Cape Town, South Africa., Chen WC; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; National Cancer Registry, a Division of the National Institute for Communicable Diseases, National Health Laboratory Service, South Africa., McBride J; Center for Proteomic & Genomic Research, Cape Town, South Africa., Bensen JT; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Mohler JL; Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Taylor JA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Andrews C; Medical Oncology, Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA., Kigongo M; Uro Care Hospital, Kampala, Uganda., Colline A; Uro Care Hospital, Kampala, Uganda., Kiddu V; Uro Care Hospital, Kampala, Uganda., Namugambe J; Uro Care Hospital, Kampala, Uganda., Owamaani S; Nikao Medical Center, Kampala, Uganda., Job K; Mulago Hospital, Nikao Medical Center, Kampala, Uganda., Masaba BJ; Mulago Hospital, Kampala, Uganda., Asiimwe F; Mulago Hospital, Kampala, Uganda., Muwanga P; Mulago Hospital, Kampala, Uganda., Namulondo J; Mulago Hospital, Kampala, Uganda., Nagawa F; Mulago Hospital, Kampala, Uganda., Kayiraba C; Mulago Hospital, Kampala, Uganda., Ogwang M; Lacor Hospital, Gulu, Uganda., Okidi R; Lacor Hospital, Gulu, Uganda., Oweka D; Lacor Hospital, Gulu, Uganda., Kitara E; Lacor Hospital, Gulu, Uganda., Obonyo J; Lacor Hospital, Gulu, Uganda., Lajul D; Lacor Hospital, Gulu, Uganda., Matovu P; Kisiizi Hospital, Rukungiri, Uganda., Muheki PA; Kisiizi Hospital, Rukungiri, Uganda., Natumanya J; Kisiizi Hospital, Rukungiri, Uganda., Agaba E; Kisiizi Hospital, Rukungiri, Uganda., Aculokin E; Kisiizi Hospital, Rukungiri, Uganda., Twongyeirwe A; Kisiizi Hospital, Rukungiri, Uganda., Mutema G; Surgipath, Kampala, Uganda., Bitamazire D; Hoima Regional Referral Hospital, Hoima, Uganda., Butler EN; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ingles SA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Rybicki BA; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Huff CD; Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Lachance J; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Multigner L; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France., Darst BF; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Rebbeck TR; Harvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA., Brureau L; CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Pointe-à-Pitre, Guadeloupe, France., Watya S; Uro Care Hospital, Kampala, Uganda; Africa Medical and Behavioural Sciences Organization (AMBSO), Wakiso, Uganda., Conti DV; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Haiman CA; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: haiman@usc.edu.
Source: European urology [Eur Urol] 2026 May; Vol. 89 (5), pp. 416-425. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE
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  Data: Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry.
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Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: haiman@usc.edu.
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          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1873-7560
          Numbering:
            – Type: volume
              Value: 89
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: European urology
              Type: main
ResultId 1