AI-assisted peripheral immune profiling reveals unconventional lymphocyte signatures associated with prognosis in soft tissue sarcoma patients.
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| Title: | AI-assisted peripheral immune profiling reveals unconventional lymphocyte signatures associated with prognosis in soft tissue sarcoma patients. |
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| Authors: | Almeida JS; Laboratory of Immunology and Oncology, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.; Center for Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Institute of Immunology, Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal., Sousa LM; Laboratory of Immunology and Oncology, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal., Couceiro P; Laboratory of Immunology and Oncology, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.; Center for Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal., Alves V; Center for Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Institute of Immunology, Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal., Rodrigues J; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Tumor Unit of the Locomotor Apparatus (UTAL), University Clinic of Orthopedics, Orthopedics Oncology Service, Coimbra Local Health Unit (ULSC), Coimbra, Portugal., Fonseca R; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Tumor Unit of the Locomotor Apparatus (UTAL), University Clinic of Orthopedics, Orthopedics Oncology Service, Coimbra Local Health Unit (ULSC), Coimbra, Portugal., Freitas-Tavares P; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Tumor Unit of the Locomotor Apparatus (UTAL), University Clinic of Orthopedics, Orthopedics Oncology Service, Coimbra Local Health Unit (ULSC), Coimbra, Portugal., Santos-Rosa M; Center for Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Institute of Immunology, Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal., Casanova JM; Center for Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Institute of Immunology, Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal.; Tumor Unit of the Locomotor Apparatus (UTAL), University Clinic of Orthopedics, Orthopedics Oncology Service, Coimbra Local Health Unit (ULSC), Coimbra, Portugal., Rodrigues-Santos P; Laboratory of Immunology and Oncology, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.; Center for Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.; Center for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal.; Institute of Immunology, Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal. |
| Source: | Frontiers in immunology [Front Immunol] 2025 Oct 27; Vol. 16, pp. 1677408. Date of Electronic Publication: 2025 Oct 27 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1677408 |
