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Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions.

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Title: Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions.
Authors: Muthuraman K; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Jackman M; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Liang Y; Adaptive Biotechnologies, Seattle, Washington, USA., Garrett ME; Adaptive Biotechnologies, Seattle, Washington, USA., Cui H; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Nguyen LVH; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Ivanochko D; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Ye C; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Pino PA; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Hicks A; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Maingot B; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA., Yusko E; Adaptive Biotechnologies, Seattle, Washington, USA., Benzeno S; Adaptive Biotechnologies, Seattle, Washington, USA., Martínez-Sobrido L; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.; International Center for Advancement of Research & Education (I· CARE), San Antonio, Texas, USA., Torrelles JB; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.; International Center for Advancement of Research & Education (I· CARE), San Antonio, Texas, USA., Gilbert AE; Adaptive Biotechnologies, Seattle, Washington, USA., Rubin BER; Adaptive Biotechnologies, Seattle, Washington, USA., Keitany G; Adaptive Biotechnologies, Seattle, Washington, USA., Jetha A; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada., Julien J-P; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Source: Journal of virology [J Virol] 2025 Dec 23; Vol. 99 (12), pp. e0152325. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions.
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  Data: <searchLink fieldCode="AU" term="%22Muthuraman+K%22">Muthuraman K</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jackman+M%22">Jackman M</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Garrett+ME%22">Garrett ME</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Cui+H%22">Cui H</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Nguyen+LVH%22">Nguyen LVH</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ivanochko+D%22">Ivanochko D</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ye+C%22">Ye C</searchLink>; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Pino+PA%22">Pino PA</searchLink>; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Hicks+A%22">Hicks A</searchLink>; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Maingot+B%22">Maingot B</searchLink>; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Yusko+E%22">Yusko E</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Benzeno+S%22">Benzeno S</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Martínez-Sobrido+L%22">Martínez-Sobrido L</searchLink>; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.; International Center for Advancement of Research & Education (I· CARE), San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Torrelles+JB%22">Torrelles JB</searchLink>; Population Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.; International Center for Advancement of Research & Education (I· CARE), San Antonio, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+AE%22">Gilbert AE</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Rubin+BER%22">Rubin BER</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Keitany+G%22">Keitany G</searchLink>; Adaptive Biotechnologies, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Jetha+A%22">Jetha A</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Julien+J-P%22">Julien J-P</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%220113724%22">Journal of virology</searchLink> [J Virol] 2025 Dec 23; Vol. 99 (12), pp. e0152325. <i>Date of Electronic Publication: </i>2025 Nov 12.
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