Eye-Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis.

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Title: Eye-Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis.
Authors: Essayagh S; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Aridi T; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Turunen T; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Choi L; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Adam H; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Patel N; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Scali ST; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Fisher MD; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Skaf K; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Csizmadia E; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Brennan P; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Sadek A; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Skaf J; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Zhan M; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Hansen E; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Shamloo M; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., DeStefino NR; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Clermont AC; The Eye Unit, Joslin Diabetes Center, Boston, Massachusetts, USA., Angolano C; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Ferran C; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; The Transplant Institute and the Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 30; Vol. 39 (22), pp. e71226.
Publication Type: Journal Article
Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
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  Data: Eye-Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis.
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  Data: <searchLink fieldCode="AU" term="%22Essayagh+S%22">Essayagh S</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Aridi+T%22">Aridi T</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Turunen+T%22">Turunen T</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Choi+L%22">Choi L</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Adam+H%22">Adam H</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Patel+N%22">Patel N</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Scali+ST%22">Scali ST</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+MD%22">Fisher MD</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Skaf+K%22">Skaf K</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Csizmadia+E%22">Csizmadia E</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Brennan+P%22">Brennan P</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sadek+A%22">Sadek A</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Skaf+J%22">Skaf J</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zhan+M%22">Zhan M</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+E%22">Hansen E</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Shamloo+M%22">Shamloo M</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22DeStefino+NR%22">DeStefino NR</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Clermont+AC%22">Clermont AC</searchLink>; The Eye Unit, Joslin Diabetes Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Angolano+C%22">Angolano C</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ferran+C%22">Ferran C</searchLink>; Department of Surgery, The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; The Transplant Institute and the Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
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